The impact of body mass index on oncological and surgical outcomes of patients undergoing nephrectomy: a systematic review and meta-analysis.

Autor: Ong CSH; Department of Urology, National University Hospital, National University Health System, Singapore, Singapore., Law TYX; Department of Urology, National University Hospital, National University Health System, Singapore, Singapore., Mok A; S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China., Ho KSC; S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China., Wang Z; Department of Urology, National University Hospital, National University Health System, Singapore, Singapore., Chiong E; Department of Urology, National University Hospital, National University Health System, Singapore, Singapore.; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tiong HY; Department of Urology, National University Hospital, National University Health System, Singapore, Singapore., Teoh JYC; S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China.
Jazyk: angličtina
Zdroj: BJU international [BJU Int] 2023 Dec; Vol. 132 (6), pp. 608-618. Date of Electronic Publication: 2023 Jul 04.
DOI: 10.1111/bju.16103
Abstrakt: Objective: To perform a systematic review and meta-analysis to evaluate the impact of body mass index (BMI) on oncological (primary) and surgical (secondary) outcomes of patients who underwent nephrectomy, as obesity or high BMI is a known risk factor for renal cell carcinoma (RCC) and predictor of poorer outcomes.
Methods: Studies were identified from four electronic databases from database inception to 2 June 2021, according to the Preferred Reporting Items for Systematic Review and Meta-analysis statement. The review protocol was registered in the International Prospective Register of Systematic Reviews with the identification number: CRD42021275124.
Results: A total of 18 studies containing 13 865 patients were identified for the final meta-analysis. Regarding oncological outcomes, higher BMI predicted higher overall survival (BMI >25 vs BMI <25 kg/m 2 : hazard ratio [HR] 0.70, 95% confidence interval [CI] 0.58-0.85), cancer-specific survival (BMI >25 vs BMI <25 kg/m 2 : HR 0.60, 95% CI 0.50-0.73; BMI 25-30 vs BMI <25 kg/m 2 : HR 0.46, 95% CI 0.23-0.95; BMI >30 vs BMI <25 kg/m 2 : HR 0.50, 95% CI 0.36-0.69), and recurrence-free survival rates (BMI >25 vs BMI <25 kg/m 2 : HR 0.72, 95% CI 0.63-0.82; BMI 25-30 vs BMI <25 kg/m 2 : HR 0.59, 95% CI 0.42-0.82). Those with a lower BMI fared better in surgical outcomes, such as operation time and warm ischaemic time, although the absolute difference was minimal and unlikely to be clinically significant. There was no difference between groups for length of hospital stay, intraoperative or postoperative complications, blood transfusion requirements, and conversion to open surgery.
Conclusion: Our study suggests that a higher BMI is associated with improved long-term oncological survival and similar perioperative outcomes as a lower BMI. More research into the underlying biological and physiological mechanisms will enable better understanding of the effect of BMI, beyond mere association, on post-nephrectomy outcomes.
(© 2023 BJU International.)
Databáze: MEDLINE
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