Betanin inhibits PI3K/AKT/mTOR/S6 signaling pathway, cell growth and death in osteosarcoma MG-63 cells.
| Autor: | Liu J; Department of Hand and Foot Micro Burn Plastic Surgery, 3201 Hospital, Hanzhong, China., Velu P; Department of Biochemistry and Biotechnology, Annamalai University, Chidambaram, India., Vijayalakshmi A; PG and Research Department of Biochemistry, Rabiammal Ahamed Maideen College for Women, Tiruvarur, India., Zareian M; Department of Life Sciences, Chalmers University of Technology, Göteborg, Sweden., Xi H; Department of Orthopeadic Surgery Area 2, Xi'an NO.3 Hospital, Xi'an, China. |
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| Jazyk: | angličtina |
| Zdroj: | Environmental toxicology [Environ Toxicol] 2023 Sep; Vol. 38 (9), pp. 2173-2181. Date of Electronic Publication: 2023 Jul 04. |
| DOI: | 10.1002/tox.23854 |
| Abstrakt: | It is possible to develop new chemopreventive compounds so that cancer cells can be targeted in an exclusive manner. Bioactive natural compounds have demonstrated to be efficient chemotherapeutic agents, safe and cost-effective. Majority of anti-cancer medications are derived from natural sources, particularly of plant origins. Betanin (betanidin-5-O-β-glucoside) is the most common betacyanin with antioxidant, anti inflammatory and anticancer properties. The present study therefore investigated the effect of betanin onosteosarcoma MG-63 cells. The mechanistic pathway of inflammatory responses, cell proliferation and apoptosis were investigated. The MG-63 cells were treated with betanin for 24 h. Betanin actions on the appearance of cell arrangements, morphological changes, ROS induced Δψ (© 2023 Wiley Periodicals LLC.) |
| Databáze: | MEDLINE |
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