Coexistence of multiple sclerosis and spinocerebellar ataxia type-8.

Autor:	Neyal N; Nur Neyal Department of Radiology, Mayo Clinic, Rochester, MN, USA., Keegan BM; Department of Neurology, Mayo Clinic, Rochester, MN, USA.; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA., Kantarci OH; Department of Neurology, Mayo Clinic, Rochester, MN, USA.; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.; Department of Medical Genetics, Mayo Clinic, Rochester, MN, USA., Zeydan B; Department of Neurology, Mayo Clinic, Rochester, MN, USA.; Department of Radiology, Mayo Clinic, Rochester, MN, USA.; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.; Women's Health Research Center, Mayo Clinic, Rochester, MN, USA.
Jazyk:	angličtina
Zdroj:	Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2023 Aug; Vol. 29 (9), pp. 1195-1198. Date of Electronic Publication: 2023 Jul 03.
DOI:	10.1177/13524585231180549
Abstrakt:	Cerebellar dysfunction is likely to cause severe and treatment-resistant disability in multiple sclerosis (MS). Certain spinocerebellar ataxia (SCA)-related alleles can increase MS susceptibility, and channel polymorphisms can impact disability measures. Following an index patient with the coexistence of MS and SCA Type-8 (SCA8) in the MS clinic, an institutional engine search for MS and hereditary ataxia coexistence was conducted but did not reveal any other cases. This extremely rare coexistence of MS and SCA8 in our index patient may be incidental; however, a yet-to-be-identified contribution of coexistent hereditary ataxia(s) to the susceptibility of a prominent progressive ataxia MS phenotype cannot be ruled out.
Databáze:	MEDLINE
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