Is poor sleep quality associated with lipid profile in elderly population? Finding from Iranian Longitudinal Study on Ageing.

Autor: Hariri M; Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.; Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran., Shamshirgaran SM; Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran.; Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran., Aminisani N; Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran.; Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran., Abasi H; Public Health Department, Neyshabur University of Medical Sciences, Neyshabur, Iran., Gholami A; Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Gholamia1@nums.ac.ir.; Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran. Gholamia1@nums.ac.ir.
Jazyk: angličtina
Zdroj: Irish journal of medical science [Ir J Med Sci] 2024 Feb; Vol. 193 (1), pp. 123-129. Date of Electronic Publication: 2023 Jul 04.
DOI: 10.1007/s11845-023-03449-9
Abstrakt: Background: Abnormal lipid profile as one of reversible cardiovascular disease risk factors might be affected by poor sleep quality.
Aim: This study aimed to assess the association between poor sleep quality and serum concentration of lipid profile in Iranian elderly population.
Methods: The study was performed on a representative sample of 3452 Iranian older people (≥60 years) who contributed in the Iranian Longitudinal Study on Ageing (IRLSA). Sleep quality was measured through the validated Persian version of Pittsburgh Sleep Quality Index (PSQI). Fasting blood samples were collected from the participants to measure plasma levels lipid profile. We used multiple linear regression model to evaluate the independent association of poor sleep quality with lipid profile.
Results: The mean age of participants was 68.0±6.7 years and 52.5% of them were male. In total, 52.4% of study population reported poor sleep quality (PSQI>5). Mean serum concentration of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) was 143.2±74.2 mg/dl, 195.6±43.2 mg/dl, 112.9±31.0 mg/dl, and 57.3±12.4 mg/dl, respectively. Poor sleep quality was significantly associated with serum levels of TG (β=17.85; P=0.006), LDL-C (β=5.45; P=0.039) and HDL-C (β=-2.13; P=0.039) after adjusting for studied covariates.
Conclusion: Our study illustrates that poor sleep quality is a risk factor for poorer lipid profile. Therefore, early behavioral or pharmacological interventions that improve sleep quality are necessary to modify lipid profile in elderly population.
(© 2023. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.)
Databáze: MEDLINE
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