Influence of the microbiome on radiotherapy-induced oral mucositis and its management: A comprehensive review.

Autor: Fernández Forné Á; Department of Radiation Oncology. Punta Europa University Hospital. Algeciras, Cádiz, Spain., García Anaya MJ; Department of Radiation Oncology, Virgen de la Victoria University Hospital, 29010 Málaga, Spain., Segado Guillot SJ; Department of Radiation Oncology, Virgen de la Victoria University Hospital, 29010 Málaga, Spain., Plaza Andrade I; Intercenter Clinical Unit of Medical Oncology, Regional and Virgen de la Victoria University Hospitals, Biomedical Research Institute of Malaga (IBIMA)-CIMES-UMA, University of Malaga, 29010 Málaga, Spain., de la Peña Fernández L; Department of Radiology and Physical Medicine. School of Medicine, University of Málaga, 29010 Málaga, Spain., Lorca Ocón MJ; Department of Radiation Oncology, Virgen de la Victoria University Hospital, 29010 Málaga, Spain., Lupiáñez Pérez Y; Department of Radiation Oncology, Virgen de la Victoria University Hospital, 29010 Málaga, Spain., Queipo-Ortuño MI; Intercenter Clinical Unit of Medical Oncology, Regional and Virgen de la Victoria University Hospitals, Biomedical Research Institute of Malaga (IBIMA)-CIMES-UMA, University of Malaga, 29010 Málaga, Spain; Department of Surgical Specialties, Biochemical and Immunology, Faculty of Medicine, University of Málaga, 29010 Malaga, Spain. Electronic address: iqueipo@uma.es., Gómez-Millán J; Department of Radiation Oncology, Virgen de la Victoria University Hospital, 29010 Málaga, Spain.
Jazyk: angličtina
Zdroj: Oral oncology [Oral Oncol] 2023 Sep; Vol. 144, pp. 106488. Date of Electronic Publication: 2023 Jul 01.
DOI: 10.1016/j.oraloncology.2023.106488
Abstrakt: Radiation-induced mucositis is the most common, debilitating and painful acute toxicity associated with active treatment in head and neck cancer area, severely affecting more than 65% of patients. Oral microbiota significantly changes during cancer therapy and appears to be involved on its pathophysiology. This review aims to present a comprehensive update of new etiopathogenic factors and treatments that may decrease the incidence of mucositis, mainly modifications of dietary interventions to modify microbiome. Despite advances in recent years, its management is mainly symptomatic opioid-based with variable results on different substances analyzed for its prevention. Immunonutrition seems to play a significant role, particularly the supplementation of compounds such as fatty acids, polyphenols or selected probiotics have shown to promote commensal bacteria diversity and reduced incidence of ulcerative mucositis. Modification of the microbiome is a promising preventive treatment for mucositis although its evidence is still scarce. Large studies are needed to demonstrate the efficacy of interventions on microbiome and its clinical impact on radiation-induced mucositis.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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