Subspace partitioning in the human prefrontal cortex resolves cognitive interference.

Autor: Weber J; Hertie Institute for Clinical Brain Research, Center for Neurology, University Medical Center Tübingen, 72076 Tübingen, Germany.; International Max Planck Research School for the Mechanisms of Mental Function and Dysfunction, University of Tübingen, 72076 Tübingen, Germany., Iwama G; Hertie Institute for Clinical Brain Research, Center for Neurology, University Medical Center Tübingen, 72076 Tübingen, Germany.; International Max Planck Research School for the Mechanisms of Mental Function and Dysfunction, University of Tübingen, 72076 Tübingen, Germany., Solbakk AK; Department of Psychology, University of Oslo, 0373 Oslo, Norway.; RITMO Centre for Interdisciplinary Studies in Rhythm, Time and Motion, University of Oslo, 0373 Oslo, Norway.; Department of Neurosurgery, Oslo University Hospital, 0372 Oslo, Norway.; Department of Neuropsychology, Helgeland Hospital, 8657 Mosjøen, Norway., Blenkmann AO; Department of Psychology, University of Oslo, 0373 Oslo, Norway.; RITMO Centre for Interdisciplinary Studies in Rhythm, Time and Motion, University of Oslo, 0373 Oslo, Norway., Larsson PG; Department of Neurosurgery, Oslo University Hospital, 0372 Oslo, Norway., Ivanovic J; Department of Neurosurgery, Oslo University Hospital, 0372 Oslo, Norway., Knight RT; Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA 94720.; Department of Psychology, UC Berkeley, Berkeley, CA 94720., Endestad T; Department of Psychology, University of Oslo, 0373 Oslo, Norway.; RITMO Centre for Interdisciplinary Studies in Rhythm, Time and Motion, University of Oslo, 0373 Oslo, Norway., Helfrich R; Hertie Institute for Clinical Brain Research, Center for Neurology, University Medical Center Tübingen, 72076 Tübingen, Germany.
Jazyk: angličtina
Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jul 11; Vol. 120 (28), pp. e2220523120. Date of Electronic Publication: 2023 Jul 03.
DOI: 10.1073/pnas.2220523120
Abstrakt: The human prefrontal cortex (PFC) constitutes the structural basis underlying flexible cognitive control, where mixed-selective neural populations encode multiple task features to guide subsequent behavior. The mechanisms by which the brain simultaneously encodes multiple task-relevant variables while minimizing interference from task-irrelevant features remain unknown. Leveraging intracranial recordings from the human PFC, we first demonstrate that competition between coexisting representations of past and present task variables incurs a behavioral switch cost. Our results reveal that this interference between past and present states in the PFC is resolved through coding partitioning into distinct low-dimensional neural states; thereby strongly attenuating behavioral switch costs. In sum, these findings uncover a fundamental coding mechanism that constitutes a central building block of flexible cognitive control.
Databáze: MEDLINE