Visual deprivation during mouse critical period reorganizes network-level functional connectivity.

Autor:	Chen S; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA., Rahn RM; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA., Bice AR; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Bice SH; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Padawer-Curry JA; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA., Hengen KB; Department of Biology, Washington University, St. Louis, MO 63130, USA., Dougherty JD; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.; Intellectual and Developmental Disabilities Research Center, Washington University, St. Louis, MO 63130, USA., Culver JP; Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Physics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 09. Date of Electronic Publication: 2023 Dec 09.
DOI:	10.1101/2023.05.30.542957
Abstrakt:	A classic example of experience-dependent plasticity is ocular dominance (OD) shift, in which the responsiveness of neurons in the visual cortex is profoundly altered following monocular deprivation (MD). It has been postulated that OD shifts also modify global neural networks, but such effects have never been demonstrated. Here, we used longitudinal wide-field optical calcium imaging to measure resting-state functional connectivity during acute (3-day) MD in mice. First, delta GCaMP6 power in the deprived visual cortex decreased, suggesting that excitatory activity was reduced in the region. In parallel, interhemispheric visual homotopic functional connectivity was rapidly reduced by the disruption of visual drive through MD and was sustained significantly below baseline state. This reduction of visual homotopic connectivity was accompanied by a reduction in parietal and motor homotopic connectivity. Finally, we observed enhanced internetwork connectivity between visual and parietal cortex that peaked at MD2. Together, these findings support the hypothesis that early MD induces dynamic reorganization of disparate functional networks including association cortices. Competing Interests: Competing Interests Statement The authors declare no conflict of interest.
Databáze:	MEDLINE
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