Interaction of mercury species with proteins: towards possible mechanism of mercurial toxicology.

Autor:	Rupa SA; Department of Chemistry, Comilla University, Cumilla 3506, Bangladesh., Patwary MAM; Department of Chemistry, Comilla University, Cumilla 3506, Bangladesh., Matin MM; Department of Chemistry, University of Chittagong, Chittagong 4331, Bangladesh., Ghann WE; Center for Nanotechnology, Department of Natural Sciences, Coppin State University, Baltimore, MD 21216, USA., Uddin J; Center for Nanotechnology, Department of Natural Sciences, Coppin State University, Baltimore, MD 21216, USA., Kazi M; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. BOX-2457, Riyadh 11451, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Toxicology research [Toxicol Res (Camb)] 2023 May 30; Vol. 12 (3), pp. 355-368. Date of Electronic Publication: 2023 May 30 (Print Publication: 2023).
DOI:	10.1093/toxres/tfad039
Abstrakt:	The nature of the binding of mercurials (organic and inorganic) and their subsequent transformations in biological systems is a matter of great debate as several different hypotheses have been proposed and none of them has been conclusively proven to explain the characteristics of Hg binding with the proteins. Thus, the chemical nature of Hg-protein binding through the possible transportation mechanism in living tissues is critically reviewed herein. Emphasis is given to the process of transportation, and binding of Hg species with selenol-containing biomolecules that are appealing for toxicological studies as well as the advancement of environmental and biological research. (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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