Sleep across the first year of life is prospectively associated with brain volume in 12-months old infants.

Autor:	Pittner K; Charité Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Medical Psychology, Berlin, Germany., Rasmussen J; Development, Health and Disease Research Program, University of California, Irvine, CA, USA.; Department of Pediatrics, University of California, Irvine, CA, USA., Lim MM; VA Portland Health Care System, Portland, OR, USA.; Oregon Health & Science University, Department of Neurology, Portland, OR, USA.; Oregon Health & Science University, Department of Behavioral Neuroscience, Portland, OR, USA.; Oregon Health & Science University, Oregon Institute of Occupational Health Sciences, Portland, OR, USA.; VA Portland Health Care System, National Center for Rehabilitative Auditory Research, Portland, OR, USA., Gilmore JH; Department of Psychiatry, University of North Carolina, Chapel Hill, USA., Styner M; Department of Psychiatry, University of North Carolina, Chapel Hill, USA., Entringer S; Charité Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Medical Psychology, Berlin, Germany.; Development, Health and Disease Research Program, University of California, Irvine, CA, USA.; Department of Pediatrics, University of California, Irvine, CA, USA., Wadhwa PD; Development, Health and Disease Research Program, University of California, Irvine, CA, USA.; Department of Pediatrics, University of California, Irvine, CA, USA.; Departments of Psychiatry and Human Behavior, Obstetrics & Gynecology, Epidemiology, University of California, Irvine, CA, USA., Buss C; Charité Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Medical Psychology, Berlin, Germany.; Development, Health and Disease Research Program, University of California, Irvine, CA, USA.; Department of Pediatrics, University of California, Irvine, CA, USA.
Jazyk:	angličtina
Zdroj:	Neurobiology of sleep and circadian rhythms [Neurobiol Sleep Circadian Rhythms] 2023 Mar 08; Vol. 14, pp. 100091. Date of Electronic Publication: 2023 Mar 08 (Print Publication: 2023).
DOI:	10.1016/j.nbscr.2023.100091
Abstrakt:	Objective: Longer sleep duration in infancy supports cognitive and affective functioning - likely through effects on brain development. From childhood through old age, there is evidence for a close link between sleep and brain volume. However, little is known about the association between sleep duration and brain volume in infancy, a developmental period of unprecedented brain maturation. This study aimed to close this gap by assessing sleep duration across the first year of life and gray and white matter volume at 12-mo age. Method: Infant sleep duration trajectories across the first year of life were based on maternal reports at 1, 3, 6, 9, and 12 months of age. Infant specific trajectories were generated by running a logarithmic regression for each infant and residualizing the resulting slopes for their intercept. Structural magnetic resonance imaging (MRI) scans were acquired at 12-mo age. Gray and white matter volume estimates were residualized for intracranial volume and age at scan. Results: Data to calculate sleep trajectories was available for 112 infants. Overall, sleep duration decreased over the course of the first year of life and was best described by a logarithmic function. Of these infants, data on brain volume was available for 45 infants at 12-mo age. Infants whose sleep duration decreased less during the first year of life relative to their intercept had, on average, greater white matter volume (β = .36, p = .02). Furthermore, average sleep duration across the first year of life, and sleep duration specifically at 6 and 9 months were positively associated with white matter volume. Sleep duration during the first year of life was not significantly associated with gray matter volume at 12-mo age. Conclusion: Sufficient sleep duration may benefit infant white matter development - possibly by supporting myelination. The fact that sleep duration was not associated with gray matter volume is in line with preclinical studies suggesting that sleep may be crucial for the balance between synaptogenesis and synaptic pruning but not necessarily relate to a net increase in gray matter volume. Supporting sleep during periods of rapid brain development and intervening in case of sleep problems may have long-term benefits for cognitive function and mental health. Competing Interests: The authors declare no conflicts of interest. (© 2023 The Authors. Published by Elsevier Inc.)
Databáze:	MEDLINE
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