Stability in cognitive classification as a function of severity of impairment and ethnicity: A longitudinal analysis.

Autor:	Arruda F; Department of Psychology, Charles E. Schmidt College of Science, Florida Atlantic University, Davie, FL., Rosselli M; Department of Psychology, Charles E. Schmidt College of Science, Florida Atlantic University, Davie, FL.; 1Florida Alzheimer's Disease Research Center, Miami Beach and Gainesville, FL, USA., Mejia Kurasz A; Department of Clinical and Health Psychology, University of Florida College of Public Health and Health Professions, Gainesville, FL, USA., Loewenstein DA; 1Florida Alzheimer's Disease Research Center, Miami Beach and Gainesville, FL, USA.; Department of Psychiatry and Behavioral Sciences and Center for Cognitive Neuroscience and Aging, Miller School of Medicine, University of Miami, Miami, FL, USA., DeKosky ST; 1Florida Alzheimer's Disease Research Center, Miami Beach and Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Lang MK; Department of Psychology, Charles E. Schmidt College of Science, Florida Atlantic University, Davie, FL., Conniff J; Department of Psychology, Charles E. Schmidt College of Science, Florida Atlantic University, Davie, FL., Vélez-Uribe I; Department of Psychology, Charles E. Schmidt College of Science, Florida Atlantic University, Davie, FL.; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA., Ahne E; Department of Psychology, Charles E. Schmidt College of Science, Florida Atlantic University, Davie, FL., Shihadeh L; Department of Psychology, Charles E. Schmidt College of Science, Florida Atlantic University, Davie, FL., Adjouadi M; 1Florida Alzheimer's Disease Research Center, Miami Beach and Gainesville, FL, USA.; Center for Advanced Technology and Education, College of Engineering, Florida International University, Miami, FL, USA., Goytizolo A; Department of Psychology, Charles E. Schmidt College of Science, Florida Atlantic University, Davie, FL., Barker WW; 1Florida Alzheimer's Disease Research Center, Miami Beach and Gainesville, FL, USA.; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA., Curiel RE; 1Florida Alzheimer's Disease Research Center, Miami Beach and Gainesville, FL, USA.; Department of Psychiatry and Behavioral Sciences and Center for Cognitive Neuroscience and Aging, Miller School of Medicine, University of Miami, Miami, FL, USA., Smith GE; 1Florida Alzheimer's Disease Research Center, Miami Beach and Gainesville, FL, USA.; Department of Clinical and Health Psychology, University of Florida College of Public Health and Health Professions, Gainesville, FL, USA., Duara R; 1Florida Alzheimer's Disease Research Center, Miami Beach and Gainesville, FL, USA.; Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, USA.
Jazyk:	angličtina
Zdroj:	Applied neuropsychology. Adult [Appl Neuropsychol Adult] 2023 Jul 03, pp. 1-14. Date of Electronic Publication: 2023 Jul 03.
DOI:	10.1080/23279095.2023.2222861
Abstrakt:	Objective: The interaction of ethnicity, progression of cognitive impairment, and neuroimaging biomarkers of Alzheimer's Disease remains unclear. We investigated the stability in cognitive status classification (cognitively normal [CN] and mild cognitive impairment [MCI]) of 209 participants (124 Hispanics/Latinos and 85 European Americans). Methods: Biomarkers (structural MRI and amyloid PET scans) were compared between Hispanic/Latino and European American individuals who presented a change in cognitive diagnosis during the second or third follow-up and those who remained stable over time. Results: There were no significant differences in biomarkers between ethnic groups in any of the diagnostic categories. The frequency of CN and MCI participants who were progressors (progressed to a more severe cognitive diagnosis at follow-up) and non-progressors (either stable through follow-ups or unstable [progressed but later reverted to a diagnosis of CN]) did not significantly differ across ethnic groups. Progressors had greater atrophy in the hippocampus (HP) and entorhinal cortex (ERC) at baseline compared to unstable non-progressors (reverters) for both ethnic groups, and more significant ERC atrophy was observed among progressors of the Hispanic/Latino group. For European Americans diagnosed with MCI, there were 60% more progressors than reverters (reverted from MCI to CN), while among Hispanics/Latinos with MCI, there were 7% more reverters than progressors. Binomial logistic regressions predicting progression, including brain biomarkers, MMSE, and ethnicity, demonstrated that only MMSE was a predictor for CN participants at baseline. However, for MCI participants at baseline, HP atrophy, ERC atrophy, and MMSE predicted progression.
Databáze:	MEDLINE
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