Type 1 diabetes could begin with alterations in innate anti-viral immunity, which are already at this stage associated with HLA risk haplotypes.

Autor: Buschard K; Department of Pathology, The Bartholin Institute, Rigshospitalet, Copenhagen, Denmark., Jensen MH; Department of Pathology, The Bartholin Institute, Rigshospitalet, Copenhagen, Denmark., Krogvold L; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway., Gerling IC; Department of Medicine, University of Tennessee, Memphis, Tennessee, USA., Dahl-Jørgensen K; Division of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway., Pedersen K; Department of Pathology, The Bartholin Institute, Rigshospitalet, Copenhagen, Denmark., Haupt-Jorgensen M; Department of Pathology, The Bartholin Institute, Rigshospitalet, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Diabetes/metabolism research and reviews [Diabetes Metab Res Rev] 2023 Oct; Vol. 39 (7), pp. e3678. Date of Electronic Publication: 2023 Jul 03.
DOI: 10.1002/dmrr.3678
Abstrakt: Aims: To investigate if HLA risk haplotypes and HbA1c levels are associated with the expression levels of innate anti-viral immune pathway genes in type 1 diabetes.
Materials and Methods: We investigated RNA expression levels of innate anti-viral immune pathway genes in laser-dissected islets from two to five tissue sections per donor from the Diabetes Virus Detection study and the network of Pancreatic Organ Donors in relation to HLA risk haplotypes (non-predisposed and predisposed) and HbA1c levels (normal, elevated, and high).
Results: The expression of innate anti-viral immune genes (TLR7, OAS1, OAS3 etc.) was significantly increased in individuals with predisposing vs non-predisposing HLA haplotypes. Also, the expression of several of the innate anti-viral immune genes from the HLA risk haplotype analysis was significantly increased in the group with high vs normal HbA1c. Furthermore, the gene expression of OAS2 was significantly increased in the group with high HbA1c vs elevated HbA1c.
Conclusions: Expression of innate anti-viral immune pathway genes was increased in individuals with predisposing HLA risk haplotypes and those with high HbA1c. This indicates that type 1 diabetes might well begin with alterations in innate anti-viral immunity, and already at this stage be associated with HLA risk haplotypes.
(© 2023 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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