Absence of association between persistent skin lesion and virological replication in severe disseminated monkeypox infection in solid organ transplant recipient.

Autor: Rousseau A; CHU Lille, Service Universitaire de Maladies Infectieuses, F-59000 Lille, France., Ferrier A; Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France., Stabler S; CHU Lille, Service Universitaire de Maladies Infectieuses, F-59000 Lille, France; Univ. Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France., Vuotto F; CHU Lille, Service Universitaire de Maladies Infectieuses, F-59000 Lille, France., Massip E; CHU Lille, Service de Dermatologie, F-59000 Lille, France., Ouafi M; CHU Lille, Service de Virologie, Institut de Microbiologie, F-59000 Lille, France., Cartier N; CHU Lille, Service de Virologie, Institut de Microbiologie, F-59000 Lille, France., Ferraris O; Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France., Alidjinou EK; CHU Lille, Service de Virologie, Institut de Microbiologie, F-59000 Lille, France., Faure E; CHU Lille, Service Universitaire de Maladies Infectieuses, F-59000 Lille, France; Univ. Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France. Electronic address: Emmanuel.faure2@chru-lille.fr.
Jazyk: angličtina
Zdroj: Infectious diseases now [Infect Dis Now] 2023 Sep; Vol. 53 (6), pp. 104749. Date of Electronic Publication: 2023 Jun 30.
DOI: 10.1016/j.idnow.2023.104749
Abstrakt: The Monkeypox (mpox) virus outbreak has been controlled worldwide. We report the case of a combined pancreas-kidney transplant recipient who presented a severe and prolonged cutaneous infection with onset of 3 successive rashes while receiving tecovirimat therapy. During follow-up, skin lesions, blood and throat samples were collected. Viral culture and mpox PCR were performed. No positive viral culture was obtained from blood and throat. The lowest mpox CT-values were obtained early after onset of skin lesions and were more likely to be associated with positive viral cultures. Furthermore, we observed persistent skin lesions up to 3 months. On these persistent lesions, mpox PCR positives were obtained but were not associated with positive viral culture after 23 days. In this immunocompromised host, who was receiving tecovirimat, in accordance with existing recommendations a 21-day isolation period appeared to be adapted. That said, isolation should not be systematically extended if complete healing of skin lesions has not been achieved.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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