Development and characterization of crosslinked k-carrageenan/sericin blend with covalent agents or thermal crosslink for indomethacin extended release.

Autor: Vieira WT; University of Campinas, School of Chemical Engineering, Albert Einstein Av., 500, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-852, Brazil., da Silva MGC; University of Campinas, School of Chemical Engineering, Albert Einstein Av., 500, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-852, Brazil., de Oliveira Nascimento L; University of Campinas, School of Pharmaceutical Sciences, Cândido Portinari, St. 200, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-871, Brazil., Vieira MGA; University of Campinas, School of Chemical Engineering, Albert Einstein Av., 500, Cidade Universitária 'Zeferino Vaz', Campinas, SP 13083-852, Brazil. Electronic address: melissagav@feq.unicamp.br.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Aug 15; Vol. 246, pp. 125558. Date of Electronic Publication: 2023 Jun 29.
DOI: 10.1016/j.ijbiomac.2023.125558
Abstrakt: Modified release of multiparticulate pharmaceutical forms is a key therapeutic strategy to reduce side effects and toxicity caused by high and repeated doses of immediate-release oral drugs. This research focused on the encapsulation of indomethacin (IND) in the crosslinked k-Car/Ser polymeric matrix by covalent and thermal methods to evaluate drug delivery modulation and properties of the crosslinked blend. Therefore, the entrapment efficiency (EE %), drug loading (DL %) and physicochemical properties of the particles were investigated. The particles presented a spherical shape and a rough surface with a mean diameter of 1.38-2.15 mm (CCA) and 1.56-1.86 mm (thermal crosslink). FTIR investigation indicated the presence of IDM in the particles and X-ray pattern showed the maintenance of crystallinity of IDM. The in vitro release in acidic medium (pH 1.2) and phosphate buffer saline solution (pH 6.8) was 1.23-6.81 % and 81-100 %, respectively. Considering the results, the formulations remained stable after 6 months. The Weibull equation was adequately fitted for all formulations and a diffusion mechanism, swelling and relaxation of chain were observed. IDM-loaded k-carrageenan/sericin/CMC increases cell viability (> 75 % for neutral red and > 81 % for MTT). Finally, all formulations present gastro-resistance, pH response and altered release and have the potential to be used as drug delivery careers.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: We do not have other relationship or activities as a conflict of interest.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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