When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging.

Autor:	Mihaylova MM; Department of Biological Chemistry and Pharmacology, College of Medicine, The Ohio State University, Columbus, OH, USA; The Ohio State University, Comprehensive Cancer Center, Wexner Medical Center, Arthur G. James Cancer Hospital, Columbus, OH, USA. Electronic address: maria.mihaylova@osumc.edu., Chaix A; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA., Delibegovic M; Aberdeen Cardiovascular and Diabetes Centre, Institute of Medical Sciences, University of Aberdeen, Foresterhill Health Campus, Aberdeen, UK., Ramsey JJ; Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA., Bass J; Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Melkani G; Department of Pathology, Division of Molecular and Cellular Pathology, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA., Singh R; Department of Medicine, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Chen Z; Department of Biochemistry and Molecular Biology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA., Ja WW; Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, FL, USA., Shirasu-Hiza M; Department of Genetics and Development, Columbia University Medical Center, New York, NY, USA., Latimer MN; Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Mattison JA; Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Thalacker-Mercer AE; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA., Dixit VD; Department of Pathology, Yale School of Medicine, New Haven, CT, USA; Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT, USA., Panda S; Regulatory Biology Lab, Salk Institute for Biological Studies, La Jolla, CA, USA., Lamming DW; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA; William S. Middleton Memorial Veterans Hospital, Madison, WI, USA. Electronic address: dlamming@medicine.wisc.edu.
Jazyk:	angličtina
Zdroj:	Cell metabolism [Cell Metab] 2023 Jul 11; Vol. 35 (7), pp. 1114-1131. Date of Electronic Publication: 2023 Jun 30.
DOI:	10.1016/j.cmet.2023.06.008
Abstrakt:	An epidemic of obesity has affected large portions of the world, increasing the risk of developing many different age-associated diseases, including cancer, cardiovascular disease, and diabetes. In contrast with the prevailing notion that "a calorie is just a calorie," there are clear differences, within and between individuals, in the metabolic response to different macronutrient sources. Recent findings challenge this oversimplification; calories from different macronutrient sources or consumed at different times of day have metabolic effects beyond their value as fuel. Here, we summarize discussions conducted at a recent NIH workshop that brought together experts in calorie restriction, macronutrient composition, and time-restricted feeding to discuss how dietary composition and feeding schedule impact whole-body metabolism, longevity, and healthspan. These discussions may provide insights into the long-sought molecular mechanisms engaged by calorie restriction to extend lifespan, lead to novel therapies, and potentially inform the development of a personalized food-as-medicine approach to healthy aging. Competing Interests: Declaration of interests D.W.L. has received funding from, and is a scientific advisory board member of, Aeovian Pharmaceuticals, which seeks to develop novel, selective mTOR inhibitors for the treatment of various diseases. S.P. is the author of the books The Circadian Code and The Circadian Diabetes Code. (Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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