Cognition's dependence on functional network integrity with age is conditional on structural network integrity.

Autor: Liu X; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. Electronic address: xl454@cam.ac.uk., Tyler LK; The Centre for Speech, Language and the Brain, Department of Psychology, University of Cambridge, Cambridge, UK., Cam-Can; Cambridge Centre for Ageing and Neuroscience (Cam-CAN), MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK., Davis SW; Department of Neurology, Duke University, School of Medicine, Durham, NC, USA., Rowe JB; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK., Tsvetanov KA; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK; The Centre for Speech, Language and the Brain, Department of Psychology, University of Cambridge, Cambridge, UK.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2023 Sep; Vol. 129, pp. 195-208. Date of Electronic Publication: 2023 Jun 06.
DOI: 10.1016/j.neurobiolaging.2023.06.001
Abstrakt: Maintaining good cognitive function is crucial for well-being across the lifespan. We proposed that the degree of cognitive maintenance is determined by the functional interactions within and between large-scale brain networks. Such connectivity can be represented by the white matter architecture of structural brain networks that shape intrinsic neuronal activity into integrated and distributed functional networks. We explored how the function-structure connectivity convergence, and the divergence of functional connectivity from structural connectivity, contribute to the maintenance of cognitive function across the adult lifespan. Multivariate analyses were used to investigate the relationship between function-structure connectivity convergence and divergence with multivariate cognitive profiles, respectively. Cognitive function was increasingly dependent on function-structure connectivity convergence as age increased. The dependency of cognitive function on connectivity was particularly strong for high-order cortical networks and subcortical networks. The results suggest that brain functional network integrity sustains cognitive functions in old age, as a function of the integrity of the brain's structural connectivity.
Competing Interests: Disclosure statement No conflict of interest.
(Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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