Smart Nanozymes for Cancer Therapy: The Next Frontier in Oncology.
Autor: | P N N; Centre for Advanced Materials and Industrial Chemistry, School of Science, STEM College, RMIT University, Melbourne, 3000, Australia., Mehla S; Centre for Advanced Materials and Industrial Chemistry, School of Science, STEM College, RMIT University, Melbourne, 3000, Australia., Begum A; Centre for Advanced Materials and Industrial Chemistry, School of Science, STEM College, RMIT University, Melbourne, 3000, Australia., Chaturvedi HK; Head Surgical Oncologist, Max Institute of Cancer Care, Delhi, 110024, India., Ojha R; Centre for Advanced Materials and Industrial Chemistry, School of Science, STEM College, RMIT University, Melbourne, 3000, Australia., Hartinger C; School of Chemical Sciences, The University of Auckland, Auckland 1142, Private Bag, 92019, New Zealand., Plebanski M; Cancer, Ageing and Vaccines Research Group, School of Health and Biomedical Sciences, STEM College, RMIT University, Melbourne, 3000, Australia., Bhargava SK; Centre for Advanced Materials and Industrial Chemistry, School of Science, STEM College, RMIT University, Melbourne, 3000, Australia. |
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Jazyk: | angličtina |
Zdroj: | Advanced healthcare materials [Adv Healthc Mater] 2023 Oct; Vol. 12 (25), pp. e2300768. Date of Electronic Publication: 2023 Jul 20. |
DOI: | 10.1002/adhm.202300768 |
Abstrakt: | Nanomaterials that mimic the catalytic activity of natural enzymes in the complex biological environment of the human body are called nanozymes. Recently, nanozyme systems have been reported with diagnostic, imaging, and/or therapeutic capabilities. Smart nanozymes strategically exploit the tumor microenvironment (TME) by the in situ generation of reactive species or by the modulation of the TME itself to result in effective cancer therapy. This topical review focuses on such smart nanozymes for cancer diagnosis, and therapy modalities with enhanced therapeutic effects. The dominant factors that guide the rational design and synthesis of nanozymes for cancer therapy include an understanding of the dynamic TME, structure-activity relationships, surface chemistry for imparting selectivity, and site-specific therapy, and stimulus-responsive modulation of nanozyme activity. This article presents a comprehensive analysis of the subject including the diverse catalytic mechanisms of different types of nanozyme systems, an overview of the TME, cancer diagnosis, and synergistic cancer therapies. The strategic application of nanozymes in cancer treatment can well be a game changer in future oncology. Moreover, recent developments may pave the way for the deployment of nanozyme therapy into other complex healthcare challenges, such as genetic diseases, immune disorders, and ageing. (© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.) |
Databáze: | MEDLINE |
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