Developmental models of motor-evoked potential features by transcranial magnetic stimulation across age groups from childhood to adulthood.

Autor: Nguyen DTA; Department of Technical Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland. thi.dao.nguyen@uef.fi., Julkunen P; Department of Technical Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.; Department of Clinical Neurophysiology, Kuopio University Hospital, POB 100, 70029 KYS, Kuopio, Finland., Säisänen L; Department of Technical Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.; Department of Clinical Neurophysiology, Kuopio University Hospital, POB 100, 70029 KYS, Kuopio, Finland., Määttä S; Department of Clinical Neurophysiology, Kuopio University Hospital, POB 100, 70029 KYS, Kuopio, Finland., Rissanen SM; Department of Technical Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland., Lintu N; Institute of Biomedicine, University of Eastern Finland, POB 162, 70211, Kuopio, Finland., Könönen M; Department of Technical Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland., Lakka T; Institute of Biomedicine, University of Eastern Finland, POB 162, 70211, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, POB 100, 70029 KYS, Kuopio, Finland.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Haapaniementie 16, 70100, Kuopio, Finland., Karjalainen PA; Department of Technical Physics, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jun 30; Vol. 13 (1), pp. 10604. Date of Electronic Publication: 2023 Jun 30.
DOI: 10.1038/s41598-023-37775-w
Abstrakt: To derive the maturation of neurophysiological processes from childhood to adulthood reflected by the change of motor-evoked potential (MEP) features. 38 participants were recruited from four groups (age mean in years [SD in months], number (males)): children (7.3 [4.2], 7(4)), preadolescents (10.3 [6.9], 10(5)), adolescents (15.3 [9.8], 11(5)), and adults (26.9 [46.2], 10(5)). The navigated transcranial magnetic stimulation was performed on both hemispheres at seven stimulation intensity (SI) levels from sub- to supra-threshold and targeted to the representative cortical area of abductor pollicis brevis muscle. MEPs were measured from three hand- and two forearm-muscles. The input-output (I/O) curves of MEP features across age groups were constructed using linear mixed-effect models. Age and SI significantly affected MEP features, whereas the stimulated side had a minor impact. MEP size and duration increased from childhood to adulthood. MEP onset- and peak-latency dropped in adolescence, particularly in hand muscles. Children had the smallest MEPs with the highest polyphasia, whereas I/O curves were similar among preadolescents, adolescents, and adults. This study illustrates some of the changing patterns of MEP features across the ages, suggesting developing patterns of neurophysiological processes activated by TMS, and to motivate studies with larger sample size.
(© 2023. The Author(s).)
Databáze: MEDLINE
Externí odkaz: