Detailed metabolite profiling and in vitro studies of Urospermum picroides as a potential functional food.

Autor: Saber FR; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el-Aini Street, Cairo 11562, Egypt. Electronic address: fatema.saber@pharma.cu.edu.eg., Elosaily AH; Pharmacognosy Department, Faculty of Pharmacy, Ahram Canadian University, Cairo, Egypt. Electronic address: Ahmed.elosaily@acu.edu.eg., Mahrous EA; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el-Aini Street, Cairo 11562, Egypt; Pharmacognosy Department, Faculty of Pharmacy, Ahram Canadian University, Cairo, Egypt. Electronic address: engy.abdelhamid@pharma.cu.edu.eg., Pecio Ł; Department of Chemistry of Natural Products, Medical University of Lublin, Lublin 20-093, Poland; Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation-State Research Institute, Czartoryskich 8, 24-100 Puławy, Poland. Electronic address: lukaszpecio@umlub.pl., Pecio S; Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation-State Research Institute, Czartoryskich 8, 24-100 Puławy, Poland. Electronic address: skozachok@iung.pulawy.pl., El-Amier YA; Botany Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt. Electronic address: yasran@mans.edu.eg., Korczak M; Microbiota Lab, Department of Pharmaceutical Biology, Medical University of Warsaw, Warsaw, Poland. Electronic address: maciej.korczak@wum.edu.pl., Piwowarski JP; Microbiota Lab, Department of Pharmaceutical Biology, Medical University of Warsaw, Warsaw, Poland. Electronic address: jakub.piwowarski@wum.edu.pl., Świątek Ł; Department of Virology with Viral Diagnostics Laboratory, Medical University of Lublin, Poland. Electronic address: lukasz.swiatek@umlub.pl., Skalicka-Woźniak K; Department of Chemistry of Natural Products, Medical University of Lublin, Lublin 20-093, Poland. Electronic address: kskalicka@pharmacognosy.org.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2023 Nov 30; Vol. 427, pp. 136677. Date of Electronic Publication: 2023 Jun 23.
DOI: 10.1016/j.foodchem.2023.136677
Abstrakt: Wild edible plants (WEP) are part of the Mediterranean culinary culture and can be used as famine foods in times of severe food shortages. Urospermum picroides is a WEP that grows under harsh conditions and represents an opportunity to expand and diversify the global food supply. However, little is known about its chemical profile. In this study, liquid chromatography coupled to HRESIMS allowed the identification of 77 metabolites in U. picroides extract, among which 12 sesquiterpene-amino acid conjugates are reported here for the first time. Due to the novelty of these conjugates, GNPS molecular networking was used to provide information on their fragmentation pathway. Further, the sesquiterpene enriched U. picroides extract showed a moderate anti-inflammatory effect in LPS-stimulated THP1-macrophages by increasing IL-10 secretion while decreasing pro-inflammatory IL-6 secretion at 50 µg/mL. Our study provides evidence for the potential use of U. picroides as an anti-inflammatory functional food and nutraceutical agent.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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