Production and radiochemistry of antimony-120m: Efforts toward Auger electron therapy with 119 Sb.

Autor: Kostelnik TI; Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada., Olson AP; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, United States., Grundmane A; Department of Chemistry, Simon Fraser University, Burnaby, BC, Canada., Ellison PA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, United States., Mynerich J; Faculty of Science, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada., Chen S; Department of Chemistry, Simon Fraser University, Burnaby, BC, Canada., Marinova A; Dzhelepov Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna 141980, Russian Federation., Randhawa P; Department of Chemistry, Simon Fraser University, Burnaby, BC, Canada., Karaivanov D; Dzhelepov Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna 141980, Russian Federation., Aluicio-Sarduy E; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, United States., Barnhart TE; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, United States., Orvig C; Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada., Ramogida CF; Department of Chemistry, Simon Fraser University, Burnaby, BC, Canada., Hoehr C; Department of Physics and Astronomy, University of Victoria, Victoria, British Columbia V8W 2Y2, Canada; Department of Computer Science, Mathematics, Physics, and Statistics, University of British Columbia Okanagan, Kelowna, British Columbia V1V 1V7, Canada., Filosofov D; Dzhelepov Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Dubna 141980, Russian Federation., Engle JW; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI 53705, United States., Radchenko V; Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada. Electronic address: vradchenko@triumf.ca.
Jazyk: angličtina
Zdroj: Nuclear medicine and biology [Nucl Med Biol] 2023 Jul-Aug; Vol. 122-123, pp. 108352. Date of Electronic Publication: 2023 Jun 12.
DOI: 10.1016/j.nucmedbio.2023.108352
Abstrakt: Targeted Meitner-Auger Therapy (TMAT) has potential for personalized treatment thanks to its subcellular dosimetric selectivity, which is distinct from the dosimetry of β - and α particle emission based Targeted Radionuclide Therapy (TRT). To date, most clinical and preclinical TMAT studies have used commercially available radionuclides. These studies showed promising results despite using radionuclides with theoretically suboptimal photon to electron ratios, decay kinetics, and electron emission spectra. Studies using radionuclides whose decay characteristics are considered more optimal are therefore important for evaluation of the full potential of Meitner-Auger therapy; 119 Sb is among the best such candidates. In the present work, we develop radiochemical purification of 120 Sb from irradiated natural tin targets for TMAT studies with 119 Sb.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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