| Autor: |
Fitzgerald DM; Departments of Chemistry and Biomedical Engineering Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02115, United States., Zhang H; Departments of Chemistry and Biomedical Engineering Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02115, United States., Bordeianu C; Departments of Chemistry and Biomedical Engineering Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02115, United States., Colson YL; Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02214, United States., Grinstaff MW; Departments of Chemistry and Biomedical Engineering Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02115, United States. |
| Abstrakt: |
We report the synthesis of block copolymers of monomethoxylated polyethylene glycol and poly(glycerol carbonate) (mPEG- b -PGC) via the ring-opening polymerization of benzyl glycidyl ether, monomethoxylated polyethylene glycol, and carbon dioxide using a cobalt salen catalyst. The resulting block copolymers display high polymer/cyclic carbonate selectivity (>99%) and, if two oxirane monomers are used, random incorporation into the polymer feed. The resulting diblock mPEG- b -PGC polymer shows promise as a nanocarrier for surfactant-free, sustained chemotherapeutic delivery. mPEG- b -PGC, with paclitaxel conjugated to the pendant primary alcohol of the glycerol polymer backbone, readily forms 175 nm diameter particles in solution and contains 4.6 wt % paclitaxel (PTX), which is released over 42 days. The mPEG- b -PGC polymer itself is noncytotoxic, whereas the PTX-loaded nanoparticles are cytotoxic to lung, breast, and ovarian cancer cell lines. |
