The Influence of Single Nucleotide Polymorphisms On Body Weight Trajectory After Bariatric Surgery: A Systematic Review.

Autor: Duarte ACS; Nutritional Genomics Research Group, Faculty of Nutrition, Federal University of Goiás (UFG), Goiânia, 74690-900, Brazil. aderuza@ufg.br., da Silva NR; Nutritional Genomics Research Group, Faculty of Nutrition, Federal University of Goiás (UFG), Goiânia, 74690-900, Brazil., Santos Gonçalves VS; Graduate Program in Public Health, University of Brasilia (UnB), Brasilia, 70910-900, Brazil., Corgosinho FC; Graduate Program in Nutrition and Health. School of Nutrition, Federal University of Goiás (UFG), Goiânia, 74690-900, Brazil.; Graduate Program in Health Science. School of Medicine, Federal University of Goiás (UFG), Goiânia, 74690-900, Brazil., de Carvalho KMB; Graduate Program in Public Health, University of Brasilia (UnB), Brasilia, 70910-900, Brazil.; Graduate Program in Human Nutrition, University of Brasilia (UnB), Brasilia, 70910-900, Brasil., Horst MA; Nutritional Genomics Research Group, Faculty of Nutrition, Federal University of Goiás (UFG), Goiânia, 74690-900, Brazil.; Graduate Program in Nutrition and Health. School of Nutrition, Federal University of Goiás (UFG), Goiânia, 74690-900, Brazil.
Jazyk: angličtina
Zdroj: Current obesity reports [Curr Obes Rep] 2023 Sep; Vol. 12 (3), pp. 280-307. Date of Electronic Publication: 2023 Jun 30.
DOI: 10.1007/s13679-023-00514-3
Abstrakt: Purpose of Review: To conduct a systematic review to summarize the results of studies on this subject and to identify whether single nucleotide polymorphisms (SNPs) are good prognostic markers for body weight trajectory after bariatric surgery.
Recent Findings: A considerable number of events can influence the body weight trajectory after bariatric surgery, and in the post-genomic era, genetic factors have been explored. This study is registered with PROSPERO (CRD42021240903). SNPs positively associated with poor weight loss after bariatric surgery were rs17702901, rs9939609, rs1360780, rs1126535, rs1137101, rs17782313, rs490683, and rs659366. Alternatively, SNPs rs2229616, rs5282087, rs490683, rs9819506, rs4771122, rs9939609, rs4846567, rs9930506, rs3813929, rs738409, rs696217, rs660339, rs659366, rs6265, rs1801260, and rs2419621 predicted a higher weight loss after bariatric surgery. Six studies performed with a genetic risk score (GRS) model presented significant associations between GRS and outcomes following bariatric surgery. This systematic review shows that, different SNPs and genetic models could be good predictors for body weight trajectory after bariatric surgery. Based on the results of the selected studies for this Systematic Review is possible to select SNPs and metabolic pathways of interest for the GRS construction to predict the outcome of bariatric surgery to be applied in future studies.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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