[Emerging links between metabolism and epigenetic regulation of muscle stem cells].

Autor:	Leduc-Gaudet JP; Meakins-Christie Laboratories et Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada - Département de Biologie Médicale, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada., Guirguis C; Centre Armand-Frappier santé biotechnologie, Institut national de la recherche scientifique (INRS), Unité de recherche mixte INRS-UQAC en santé durable, Laval, Québec, Canada., Sincennes MC; Centre Armand-Frappier santé biotechnologie, Institut national de la recherche scientifique (INRS), Unité de recherche mixte INRS-UQAC en santé durable, Laval, Québec, Canada.
Jazyk:	francouzština
Zdroj:	Medecine sciences : M/S [Med Sci (Paris)] 2023 Jun-Jul; Vol. 39 (6-7), pp. 530-536. Date of Electronic Publication: 2023 Jun 30.
DOI:	10.1051/medsci/2023084
Abstrakt:	Muscle regeneration in response to injury or exercise relies on the ability of muscle stem cells to proliferate and differentiate to repair the damage. In the absence of damage, muscle stem cells are quiescent: they do not proliferate and have a very low metabolism. Recent studies have linked the metabolic state of the adult muscle stem cell to its epigenetic regulation. This article synthesizes the known concepts about histone modifications and metabolic pathways found in quiescent muscle stem cells, as well as the metabolic and epigenetic changes leading to muscle stem cell activation in response to injury. Here, we discuss the heterogeneity in quiescent stem cell metabolism and compare the metabolism of quiescent and activated muscle stem cells, and describe the epigenetic changes related to their activation. We also discuss the involvement of SIRT1, an important effector of muscle stem cells metabolism, together with the effects of aging and caloric restriction. (© 2023 médecine/sciences – Inserm.)
Databáze:	MEDLINE
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