Influence of depression and interpersonal support on adherence to antiretroviral therapy among people living with HIV.

Autor: Nutor JJ; Department of Family Health Care Nursing, School of Nursing, University of California San Francisco, San Francisco, CA, USA. jerry.nutor@ucsf.edu., Gyamerah AO; Department of Community Health and Health Behavior, University of Buffalo, Buffalo, NY, USA., Alhassan RK; Centre for Health Policy and Implementation Research, Institute of Health Research, University of Health and Allied Sciences, Ho, Ghana., Duah HO; College of Nursing, University of Cincinnati, Cincinnati, OH, USA., Thompson RGA; Language Center, College of Humanities, University of Ghana, Accra, Ghana.; Africa Interdisciplinary Research Institute, Accra, Ghana., Wilson N; Department of Community Health Systems, School of Nursing, University of California San Francisco, San Francisco, CA, USA., Harris O; Department of Community Health Systems, School of Nursing, University of California San Francisco, San Francisco, CA, USA., Gutierrez J; Department of Family Health Care Nursing, School of Nursing, University of California San Francisco, San Francisco, CA, USA., Hoffmann TJ; Department of Epidemiology and Biostatistics, Office of Research, School of Nursing, University of California, San Francisco, San Francisco, CA, USA., Getahun M; Institute for Global Health Sciences, University of California, San Francisco, San Francisco, CA, USA., Santos GM; Department of Community Health Systems, School of Nursing, University of California San Francisco, San Francisco, CA, USA.
Jazyk: angličtina
Zdroj: AIDS research and therapy [AIDS Res Ther] 2023 Jun 29; Vol. 20 (1), pp. 42. Date of Electronic Publication: 2023 Jun 29.
DOI: 10.1186/s12981-023-00538-8
Abstrakt: Background: Poor adherence and under-utilization of antiretroviral therapy (ART) services have been major setbacks to achieving 95-95-95 policy goals in Sub-Saharan Africa. Social support and mental health challenges may serve as barriers to accessing and adhering to ART but are under-studied in low-income countries. The purpose of this study was to examine the association of interpersonal support and depression scores with adherence to ART among persons living with HIV (PLWH) in the Volta region of Ghana.
Methods: We conducted a cross-sectional survey among 181 PLWH 18 years or older who receive care at an ART clinic between November 2021 and March 2022. The questionnaire included a 6-item simplified ART adherence scale, the 20-item Center for Epidemiologic Studies Depression Scale (CES-D), and the 12-item Interpersonal Support Evaluation List-12 (ISEL-12). We first used a chi-squared or Fisher's exact test to assess the association between these and additional demographic variables with ART adherence status. We then built a stepwise multivariable logistic regression model to explain ART adherence.
Results: ART adherence was 34%. The threshold for depression was met by 23% of participants, but it was not significantly associated with adherence in multivariate analysis(p = 0.25). High social support was reported by 48.1%, and associated with adherence (p = 0.033, aOR = 3.45, 95% CI = 1.09-5.88). Other factors associated with adherence included in the multivariable model included not disclosing HIV status (p = 0.044, aOR = 2.17, 95% CI = 1.03-4.54) and not living in an urban area (p = 0.00037, aOR = 0.24, 95% CI = 0.11-0.52).
Conclusion: Interpersonal support, rural residence, and not disclosing HIV status were independent predictors of adherence to ART in the study area.
(© 2023. The Author(s).)
Databáze: MEDLINE
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