The Association Between Pregnancy Timing and Cumulative Exposure on Survival in Melanoma.

Autor: Bateni SB; Division of General Surgery, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Division of General Surgery, University of Toronto, Toronto, ON, Canada.; Division of Surgical Oncology, Department of General Surgery, University of Alabama at Birmingham, Birmingham, AL, USA., Sutradhar R; Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Everett K; ICES, Toronto, ON, Canada., Wright FC; Division of General Surgery, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Division of General Surgery, University of Toronto, Toronto, ON, Canada., Hong NJL; Division of General Surgery, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. nicole.lookhong@sunnybrook.ca.; Division of General Surgery, University of Toronto, Toronto, ON, Canada. nicole.lookhong@sunnybrook.ca.
Jazyk: angličtina
Zdroj: Annals of surgical oncology [Ann Surg Oncol] 2023 Oct; Vol. 30 (11), pp. 6332-6338. Date of Electronic Publication: 2023 Jun 29.
DOI: 10.1245/s10434-023-13819-3
Abstrakt: Background: As melanoma is common among young women, the impact of pregnancy on melanoma prognosis is of interest.
Objective: The purpose of this study was to examine the association between pregnancy and survival in female melanoma patients of childbearing age.
Methods: We performed a population-level, retrospective cohort study of women of childbearing age (18-45 years) diagnosed with melanoma from 2007 to 2017 using administrative data from Ontario, Canada. Patients were categorized according to pregnancy status (i.e. pregnancy before [conception from 60 to 13 months prior to melanoma], pregnancy-associated [conception 12 months prior to and after], and pregnancy after [conception 12 months after] melanoma). Cox models were used to examine melanoma-specific survival (MSS) and overall survival (OS) associated with pregnancy status.
Results: Of 1312 women with melanoma, most did not experience pregnancy (84.1%), with 7.6% experiencing a pregnancy-associated melanoma and 8.2% experiencing a pregnancy after melanoma. Pregnancy before melanoma occurred in 18.1% of patients. Pregnancy before (hazard ratio [HR] 0.67, 95% confidence interval [CI] 0.35-1.28), associated (HR 1.15, 95% CI 0.45-2.97), and after melanoma (HR 0.39, 95% CI 0.13-1.11) was not associated with a difference in MSS compared with those who did not experience a pregnancy during these time periods. Pregnancy status was also not associated with a difference in OS (p > 0.05). Cumulative weeks pregnant were not associated with a difference in MSS (4-week HR 0.99, 95% CI 0.92-1.07) or OS (4-week HR 1.00, 95% CI 0.94-1.06).
Conclusions: In this population-level analysis of female melanoma patients of childbearing age, pregnancy was not associated with a difference in survival, suggesting that pregnancy is not associated with a worse melanoma prognosis.
(© 2023. Crown.)
Databáze: MEDLINE
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