Recent advances in chromosome capture techniques unraveling 3D genome architecture in germ cells, health, and disease.

Autor: Pandupuspitasari NS; Laboratory of Animal Nutrition and Feed Science, Animal Science Department, Faculty of Animal and Agricultural Sciences, Universitas Diponegoro, Semarang, Indonesia. shin_tse@yahoo.com., Khan FA; Research Center for Animal Husbandry, National Research and Innovation Agency, Bogor, Indonesia., Huang C; Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong, 226001, China., Ali A; Laboratory of Molecular Biology and Genomics, Faculty of Science and Technology, University of Central Punjab, Lahore, Pakistan., Yousaf MR; Laboratory of Molecular Biology and Genomics, Faculty of Science and Technology, University of Central Punjab, Lahore, Pakistan., Shakeel F; Laboratory of Molecular Biology and Genomics, Faculty of Science and Technology, University of Central Punjab, Lahore, Pakistan., Putri EM; Research Center for Animal Husbandry, National Research and Innovation Agency, Bogor, Indonesia., Negara W; Research Center for Animal Husbandry, National Research and Innovation Agency, Bogor, Indonesia., Muktiani A; Laboratory of Animal Nutrition and Feed Science, Animal Science Department, Faculty of Animal and Agricultural Sciences, Universitas Diponegoro, Semarang, Indonesia., Prasetiyono BWHE; Laboratory of Feed Technology, Animal Science Department, Faculty of Animal and Agricultural Sciences Universitas Diponegoro, Semarang, Indonesia., Kustiawan L; Laboratory of Animal Nutrition and Feed Science, Animal Science Department, Faculty of Animal and Agricultural Sciences, Universitas Diponegoro, Semarang, Indonesia., Wahyuni DS; Research Center for Animal Husbandry, National Research and Innovation Agency, Bogor, Indonesia.
Jazyk: angličtina
Zdroj: Functional & integrative genomics [Funct Integr Genomics] 2023 Jun 29; Vol. 23 (3), pp. 214. Date of Electronic Publication: 2023 Jun 29.
DOI: 10.1007/s10142-023-01146-5
Abstrakt: In eukaryotes, the genome does not emerge in a specific shape but rather as a hierarchial bundle within the nucleus. This multifaceted genome organization consists of multiresolution cellular structures, such as chromosome territories, compartments, and topologically associating domains, which are frequently defined by architecture, design proteins including CTCF and cohesin, and chromatin loops. This review briefly discusses the advances in understanding the basic rules of control, chromatin folding, and functional areas in early embryogenesis. With the use of chromosome capture techniques, the latest advancements in technologies for visualizing chromatin interactions come close to revealing 3D genome formation frameworks with incredible detail throughout all genomic levels, including at single-cell resolution. The possibility of detecting variations in chromatin architecture might open up new opportunities for disease diagnosis and prevention, infertility treatments, therapeutic approaches, desired exploration, and many other application scenarios.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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