Localized periodontitis severity associated with carotid intima-media thickness in young adults: CHIEF atherosclerosis study.

Autor: Tsai KZ; Department of Internal Medicine, Hualien Armed Forces General Hospital, No. 100, Jinfeng St., Hualien City, 970, Taiwan.; Department of Stomatology of Periodontology, Mackay Memorial Hospital, Taipei, Taiwan.; Department of Dentistry, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan., Huang WC; Department of Critical Care Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan., Chang YC; School of Nursing and Graduate Institute of Nursing, China Medical University, Taichung, 406, Taiwan., Kwon Y; Department of Medicine, University of Washington, Seattle, WA, USA., Sui X; Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA., Lavie CJ; John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, LA, USA., Lin GM; Department of Internal Medicine, Hualien Armed Forces General Hospital, No. 100, Jinfeng St., Hualien City, 970, Taiwan. farmer507@yahoo.com.tw.; Department of Internal Medicine, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan. farmer507@yahoo.com.tw.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jun 29; Vol. 13 (1), pp. 10523. Date of Electronic Publication: 2023 Jun 29.
DOI: 10.1038/s41598-023-37840-4
Abstrakt: This study aimed to investigate the association of periodontitis with subclinical atherosclerosis in young adults. In total, 486 non-diabetic military personnel were included in Taiwan. Carotid intima-media thickness (cIMT) was assessed utilizing sonography for subclinical atherosclerosis. Periodontitis severity was defined based on the 2017 US/European consensus. Mean cIMT was compared by analysis of covariance (ANCOVA), and multiple logistic regression model was used to determine the association of periodontitis severity and the highest quintile of cIMT (≥ 0.8 mm) with adjustments for age, sex, metabolic risk factors and leukocyte counts. The mean cIMT increased in those with greater stages (periodontal health (N = 349): 0.65 mm, Stage I (N = 41): 0.72 mm, Stage II (N = 57): 0.74 mm and Stage III: 0.76 mm, respectively, p < 0.01). In multiple logistic regression, a dose-response association from Stage I to Stage III periodontitis for cIMT ≥ 0.8 mm was also found [ORs and 95% CIs 1.41 (0.60-3.29), 1.62 (0.79-3.31) and 3.20 (1.42-7.18)]. Leucocyte counts ≥ 7.6 × 10 3 /µL (the highest quintile) was associated with cIMT ≥ 0.8 mm [OR 1.86 (1.11-3.12)], while no association existed for other metabolic risk factors. In conclusion, severe periodontitis and leukocyte counts are independent risk factors of increased cIMT, emphasizing the critical role of inflammation in subclinical atherosclerosis.
(© 2023. The Author(s).)
Databáze: MEDLINE
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