Three players in the 'toxic affair' between botulinum neurotoxin type A and neurons.

Autor: Rossetto O; Department of Biomedical Sciences, University of Padova, Padova, Italy; Consiglio Nazionale delle Ricerche, Institute of Neuroscience, University of Padova, Padova, Italy. Electronic address: ornella.rossetto@unipd.it., Pirazzini M; Department of Biomedical Sciences, University of Padova, Padova, Italy., Montecucco C; Department of Biomedical Sciences, University of Padova, Padova, Italy; Consiglio Nazionale delle Ricerche, Institute of Neuroscience, University of Padova, Padova, Italy.
Jazyk: angličtina
Zdroj: Trends in neurosciences [Trends Neurosci] 2023 Sep; Vol. 46 (9), pp. 695-697. Date of Electronic Publication: 2023 Jun 27.
DOI: 10.1016/j.tins.2023.06.001
Abstrakt: Joensuu and colleagues have recently shown that botulinum neurotoxin (BoNT) type A exploits a heterotrimeric complex in the presynaptic membrane to bind to and enter neurons using a Trojan horse-like mechanism. Similar processes may be relevant to the neuronal entry of different botulinum toxin serotypes and other neuropathogens.
Competing Interests: Declaration of interests The authors declare no conflicts of interest.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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