Fatal neonatal listeriosis following L. monocytogenes horizontal transmission highlights neonatal susceptibility to orally acquired listeriosis.

Autor:	Charlier C; Institut Pasteur, Université Paris Cité, INSERM U1117, Biology of Infection Unit, 75015 Paris, France; Institut Pasteur, National Reference Center and WHO Collaborating Center Listeria, 75015 Paris, France; Cochin University Hospital, Division of Infectious Diseases and Tropical Medicine, APHP, Institut Imagine, 75015 Paris, France. Electronic address: caroline.charlier@pasteur.fr., Noel C; Groupe Hospitalier Sud Ile-de-France, 77000 Melun, France., Hafner L; Institut Pasteur, Université Paris Cité, INSERM U1117, Biology of Infection Unit, 75015 Paris, France., Moura A; Institut Pasteur, Université Paris Cité, INSERM U1117, Biology of Infection Unit, 75015 Paris, France; Institut Pasteur, National Reference Center and WHO Collaborating Center Listeria, 75015 Paris, France., Mathiaud C; Groupe Hospitalier Sud Ile-de-France, 77000 Melun, France., Pitsch A; Groupe Hospitalier Sud Ile-de-France, 77000 Melun, France., Meziane C; Groupe Hospitalier Sud Ile-de-France, 77000 Melun, France., Jolly-Sanchez L; Groupe Hospitalier Sud Ile-de-France, 77000 Melun, France., de Pontfarcy A; Groupe Hospitalier Sud Ile-de-France, 77000 Melun, France., Diamantis S; Groupe Hospitalier Sud Ile-de-France, 77000 Melun, France., Bracq-Dieye H; Institut Pasteur, National Reference Center and WHO Collaborating Center Listeria, 75015 Paris, France., Disson O; Institut Pasteur, Université Paris Cité, INSERM U1117, Biology of Infection Unit, 75015 Paris, France., Thouvenot P; Institut Pasteur, National Reference Center and WHO Collaborating Center Listeria, 75015 Paris, France., Valès G; Institut Pasteur, National Reference Center and WHO Collaborating Center Listeria, 75015 Paris, France., Tessaud-Rita N; Institut Pasteur, National Reference Center and WHO Collaborating Center Listeria, 75015 Paris, France., Tourdjman M; Santé publique France, 94410 Saint Maurice, France., Leclercq A; Institut Pasteur, National Reference Center and WHO Collaborating Center Listeria, 75015 Paris, France., Lecuit M; Institut Pasteur, Université Paris Cité, INSERM U1117, Biology of Infection Unit, 75015 Paris, France; Institut Pasteur, National Reference Center and WHO Collaborating Center Listeria, 75015 Paris, France; Necker-Enfants Malades University Hospital, Division of Infectious Diseases and Tropical Medicine, APHP, Institut Imagine, 75015 Paris, France. Electronic address: marc.lecuit@pasteur.fr.
Jazyk:	angličtina
Zdroj:	Cell reports. Medicine [Cell Rep Med] 2023 Jul 18; Vol. 4 (7), pp. 101094. Date of Electronic Publication: 2023 Jun 28.
DOI:	10.1016/j.xcrm.2023.101094
Abstrakt:	We report a case of fulminant fatal neonatal listeriosis due to horizontal transmission of Listeria monocytogenes (Lm) in a neonatal double room. Genomic analyses reveal a close genetic relationship between clinical isolates, supporting cross-contamination. Oral inoculation experiments in adult and neonatal mice show that neonates are susceptible to a low Lm inoculum and that this susceptibility results from the immaturity of the neonatal gut microbiota. Infected neonates should therefore be isolated for as long as they shed Lm in their feces to avoid horizontal transmission and its dire consequences. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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