Delineating the Seasonality of Varicella and Its Association With Climate in the Tropical Country of Colombia.

Autor:	Barrero Guevara LA; Max Planck Institute for Infection Biology, Infectious Disease Epidemiology Group, Berlin, Germany.; Institute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany., Goult E; Max Planck Institute for Infection Biology, Infectious Disease Epidemiology Group, Berlin, Germany., Rodriguez D; Medicine Department, Universidad de los Andes, Bogotá, Colombia., Hernandez LJ; Medicine Department, Universidad de los Andes, Bogotá, Colombia., Kaufer B; Institute of Virology, Freie Universität Berlin, Berlin, Germany., Kurth T; Institute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany., Domenech de Cellès M; Max Planck Institute for Infection Biology, Infectious Disease Epidemiology Group, Berlin, Germany.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2023 Sep 15; Vol. 228 (6), pp. 674-683.
DOI:	10.1093/infdis/jiad244
Abstrakt:	Background: Varicella causes a major health burden in many low- to middle-income countries located in tropical regions. Because of the lack of surveillance data, however, the epidemiology of varicella in these regions remains uncharacterized. In this study, based on an extensive dataset of weekly varicella incidence in children ≤10 during 2011-2014 in 25 municipalities, we aimed to delineate the seasonality of varicella across the diverse tropical climates of Colombia. Methods: We used generalized additive models to estimate varicella seasonality, and we used clustering and matrix correlation methods to assess its correlation with climate. Furthermore, we developed a mathematical model to examine whether including the effect of climate on varicella transmission could reproduce the observed spatiotemporal patterns. Results: Varicella seasonality was markedly bimodal, with latitudinal changes in the peaks' timing and amplitude. This spatial gradient strongly correlated with specific humidity (Mantel statistic = 0.412, P = .001) but not temperature (Mantel statistic = 0.077, P = .225). The mathematical model reproduced the observed patterns not only in Colombia but also México, and it predicted a latitudinal gradient in Central America. Conclusions: These results demonstrate large variability in varicella seasonality across Colombia and suggest that spatiotemporal humidity fluctuations can explain the calendar of varicella epidemics in Colombia, México, and potentially in Central America. Competing Interests: Potential conflicts of interest. TK received research grants from the Gemeinsamer Bundesausschuss ([G-BA] Federal Joint Committee, Germany) and the Bundesministerium für Gesundheit ([BMG] Federal Ministry of Health, Germany), outside the submitted work. He has also received personal compensation from Eli Lilly and Company, Teva Pharmaceuticals, TotalEnergies SE, the BMJ, and Frontiers. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu