Is chimerism associated with cancer across the tree of life?

Autor: Kapsetaki SE; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, United States of America.; Biodesign Institute, Center for Biocomputing, Security and Society, Arizona State University, Tempe, AZ, United States of America., Fortunato A; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, United States of America.; Biodesign Institute, Center for Biocomputing, Security and Society, Arizona State University, Tempe, AZ, United States of America., Compton Z; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, United States of America.; Biodesign Institute, Center for Biocomputing, Security and Society, Arizona State University, Tempe, AZ, United States of America.; School of Life Sciences, Arizona State University, Tempe, AZ, United States of America., Rupp SM; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, United States of America.; Biodesign Institute, Center for Biocomputing, Security and Society, Arizona State University, Tempe, AZ, United States of America., Nour Z; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, United States of America.; Biodesign Institute, Center for Biocomputing, Security and Society, Arizona State University, Tempe, AZ, United States of America., Riggs-Davis S; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, United States of America.; Biodesign Institute, Center for Biocomputing, Security and Society, Arizona State University, Tempe, AZ, United States of America., Stephenson D; Department of Psychology, Arizona State University, Tempe, AZ, United States of America., Duke EG; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, United States of America.; Department of Clinical Sciences, North Carolina State University, Raleigh, NC, United States of America.; Exotic Species Cancer Research Alliance, North Carolina State University, Raleigh, NC, United States of America., Boddy AM; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, United States of America.; Department of Anthropology, University of California, Santa Barbara, CA, United States of America., Harrison TM; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, United States of America.; Department of Clinical Sciences, North Carolina State University, Raleigh, NC, United States of America.; Exotic Species Cancer Research Alliance, North Carolina State University, Raleigh, NC, United States of America., Maley CC; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, United States of America.; Biodesign Institute, Center for Biocomputing, Security and Society, Arizona State University, Tempe, AZ, United States of America.; School of Life Sciences, Arizona State University, Tempe, AZ, United States of America., Aktipis A; Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, United States of America.; Department of Psychology, Arizona State University, Tempe, AZ, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Jun 29; Vol. 18 (6), pp. e0287901. Date of Electronic Publication: 2023 Jun 29 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0287901
Abstrakt: Chimerism is a widespread phenomenon across the tree of life. It is defined as a multicellular organism composed of cells from other genetically distinct entities. This ability to 'tolerate' non-self cells may be linked to susceptibility to diseases like cancer. Here we test whether chimerism is associated with cancers across obligately multicellular organisms in the tree of life. We classified 12 obligately multicellular taxa from lowest to highest chimerism levels based on the existing literature on the presence of chimerism in these species. We then tested for associations of chimerism with tumour invasiveness, neoplasia (benign or malignant) prevalence and malignancy prevalence in 11 terrestrial mammalian species. We found that taxa with higher levels of chimerism have higher tumour invasiveness, though there was no association between malignancy or neoplasia and chimerism among mammals. This suggests that there may be an important biological relationship between chimerism and susceptibility to tissue invasion by cancerous cells. Studying chimerism might help us identify mechanisms underlying invasive cancers and also could provide insights into the detection and management of emerging transmissible cancers.
Competing Interests: We declare we do not have conflicts of interest.
(Copyright: © 2023 Kapsetaki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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