Performance on complex memory tests is associated with β-amyloid in individuals at risk of developing Alzheimer's disease.

Autor: Kjeldsen PL; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark.; Department of Neurology, Aalborg University Hospital, Aalborg, Denmark., Damholdt MF; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Psychology, Aarhus University, Aarhus, Denmark., Madsen LS; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Centre of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark., Nissen PH; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark., Aanerud JFA; Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark., Parbo P; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark., Ismail R; Department of Nuclear Medicine, Sygehus Lillebaelt, Vejle, Denmark., Kaasing M; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Centre of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark., Eskildsen SF; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Centre of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark., Østergaard L; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Centre of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark., Brooks DJ; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.; Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, Denmark.; Translational and Clinical Research Institute, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.
Jazyk: angličtina
Zdroj: Journal of neuropsychology [J Neuropsychol] 2024 Mar; Vol. 18 (1), pp. 120-135. Date of Electronic Publication: 2023 Jun 29.
DOI: 10.1111/jnp.12332
Abstrakt: The pathophysiological development of Alzheimer's disease (AD) begins in the brain years before the onset of clinical symptoms. The accumulation of beta-amyloid (Aβ) is thought to be the first cortical pathology to occur. Carrying one apolipoprotein E (APOE) ε4 allele increases the risk of developing AD at least 2-3 times and is associated with earlier Aβ accumulation. Although it is difficult to identify Aβ-related cognitive impairment in early AD with standard cognitive tests, more sensitive memory tests may be able to do this. We sought to examine associations between Aβ and performance on three tests within three subdomains of memory, verbal, visual, and associative memory, to elucidate which of these tests were sensitive to Aβ-related cognitive impairment in at-risk subjects. 55 APOE ε4 carriers underwent MRI, 11 C-Pittsburgh Compound B (PiB) PET, and cognitive testing. A composite cortical PiB SUVR cut-off score of 1.5 was used to categorise subjects as either APOE ε4 Aβ+ or APOE ε4 Aβ-. Correlations were carried out using cortical surface analysis. In the whole APOE ε4 group, we found significant correlations between Aβ load and performance on verbal, visual, and associative memory tests in widespread cortical areas, the strongest association being with performance on associative memory tests. In the APOE ε4 Aβ+ group, we found significant correlations between Aβ load and performance of verbal and associative, but not visual, memory in localised cortical areas. Performance on verbal and associative memory tests provides sensitive markers of early Aβ-related cognitive impairment in at-risk subjects.
(© 2023 The Authors. Journal of Neuropsychology published by John Wiley & Sons Ltd on behalf of The British Psychological Society.)
Databáze: MEDLINE
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