Complement-mediated immune mechanisms in allergy.

Autor: Laumonnier Y; Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany.; Institute for Nutritional Medicine, University of Lübeck, Lübeck, Germany.; Airway Research Center North, Member of the German Center for Lung Research (DZL), Lübeck, Germany., Korkmaz RÜ; Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany., Nowacka AA; Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany., Köhl J; Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany.; Airway Research Center North, Member of the German Center for Lung Research (DZL), Lübeck, Germany.; Division of Immunobiology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, USA.
Jazyk: angličtina
Zdroj: European journal of immunology [Eur J Immunol] 2023 Oct; Vol. 53 (10), pp. e2249979. Date of Electronic Publication: 2023 Jul 09.
DOI: 10.1002/eji.202249979
Abstrakt: Allergic conditions are associated with canonical and noncanonical activation of the complement system leading to the release of several bioactive mediators with inflammatory and immunoregulatory properties that regulate the immune response in response to allergens during the sensitization and/or the effector phase of allergic diseases. Further, immune sensors of complement and regulator proteins of the cascade impact on the development of allergies. These bioactive mediators comprise the small and large cleavage fragments of C3 and C5. Here, we provide an update on the multiple roles of immune sensors, regulators, and bioactive mediators of complement in allergic airway diseases, food allergies, and anaphylaxis. A particular emphasis is on the anaphylatoxins C3a and C5a and their receptors, which are expressed on many of the effector cells in allergy such as mast cells, eosinophils, basophils, macrophages, and neutrophils. Also, we will discuss the multiple pathways, by which the anaphylatoxins initiate and control the development of maladaptive type 2 immunity including their impact on innate lymphoid cell recruitment and activation. Finally, we briefly comment on the potential to therapeutically target the complement system in different allergic conditions.
(© 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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