Pharmacokinetic disposition of marbofloxacin after intramuscular administration in estuarine crocodiles (Crocodylus porosus).
| Autor: | Yalong M; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Poapolathep S; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Giorgi M; Department of Veterinary Sciences, University of Pisa, Pisa, Italy., Khidkhan K; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Klangkaew N; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Phaochoosak N; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand., Chaiyabutr N; Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand., Wongwaipairoj T; Wongveerakit Crocodile Farm, Bho Ploi, Kanchanaburi, Thailand., Poapolathep A; Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2024 Jan; Vol. 47 (1), pp. 48-53. Date of Electronic Publication: 2023 Jun 28. |
| DOI: | 10.1111/jvp.13400 |
| Abstrakt: | To date, the pharmacokinetics of fluoroquinolones in estuarine crocodiles (Crocodylus porosus) have been reported for enrofloxacin but not for marbofloxacin (MBF), which is a broad-spectrum antibiotic used only in veterinary medicine. This study investigated the pharmacokinetics of MBF after intramuscular administration at two difference dosages (2 and 4 mg/kg body weight) in estuarine crocodiles and estimated pharmacokinetic/pharmacodynamic (PK/PD) surrogate parameters for the optimization of dosage regimens. Ten treated estuarine crocodiles were divided into two groups (n = 5) using a randomization procedure according to a parallel study design. Blood samples were collected at assigned times up to 168 h. MBF plasma samples were cleaned up using liquid-liquid extraction and analyzed using a validated high-performance liquid chromatography method with fluorescence detection. A non-compartment approach was used to fit the plasma concentration of MBF vs time curve for each crocodile. The plasma concentrations of MBF were quantifiable for up to 168 h in both groups. The elimination half-life values of MBF were long (33.99 and 39.28 h for 2 and 4 mg/kg, respectively) with no significant differences between the groups. The average plasma protein binding of MBF was 30.85%. According to the surrogated PK/PD parameter (AUC (© 2023 John Wiley & Sons Ltd.) |
| Databáze: | MEDLINE |
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