Formulation and Evaluation of Chitosan-PLGA Biocomposite Scaffolds Incorporated with Quercetin Liposomes Made by QbD Approach for Improved Healing of Oral Lesions.

Autor: Munot NM; Technical Lead, HCL Technologies, Chennai, Tamil Nadu, 600058, India., Shinde YD; Department of Pharmaceutics, STES's Smt. Kashibai Navale College of Pharmacy, Kondhwa (Bk), Affiliated to Savitribai Phule Pune University, Pune, 411048, India., Shah P; Maliba Pharmacy College, Bardoli, Gujarat, 394350, India., Patil A; Department of Pharmaceutics, D Y Patil College of Pharmacy, Kolhapur, 416006, India., Patil SB; Department of Pharmacology, Dr. Shivajirao Kadam College of Pharmacy, Kasbe Digraj, Maharashtra, MS, 416305, India., Bhinge SD; Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, MS, 415404, India. somu1245@yahoo.co.in.
Jazyk: angličtina
Zdroj: AAPS PharmSciTech [AAPS PharmSciTech] 2023 Jun 28; Vol. 24 (6), pp. 147. Date of Electronic Publication: 2023 Jun 28.
DOI: 10.1208/s12249-023-02584-x
Abstrakt: The current research aims to develop and evaluate chitosan-PLGA biocomposite scaffolds in combination with quercetin liposomes to accomplish the desired impact in oral lesions where pharmacotherapeutic agent treatment through circulation could only reach the low content at the target. Optimization of quercetin-loaded liposomes was carried out using 3 2 factorial design. The preparation of porous scaffolds comprising produced quercetin-loaded liposomes by thin-film method was carried out in the current study using a unique strategy combining solvent casting and gas foaming procedures. The prepared scaffolds were tested for physicochemical properties, in vitro quercetin release study, ex vivo drug permeation and retention research using goat mucosa, antibacterial activity, and cell migration studies on fibroblast L929 cell lines. Improved cell growth and migration were seen in the order control < liposomes < proposed system. The proposed system has been examined for its biological and physicochemical features, and it has the potential to be utilized as an efficient therapy for oral lesions.
(© 2023. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.)
Databáze: MEDLINE
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