Acute stress induces long-term metabolic, functional, and structural remodeling of the heart.

Autor: Yoganathan T; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France. thulacigayoganathan@calicolabs.com., Perez-Liva M; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Nuclear Physics Group and IPARCOS, Department of Structure of Matter, Thermal Physics and Electronics, CEI Moncloa, Universidad Complutense de Madrid, 28040, Madrid, Spain., Balvay D; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Université Paris Cité, Plateforme d'Imageries du Vivant, PARCC, F-75015, Paris, France., Le Gall M; Université Paris Cité, P53 proteom'IC facility, Institut Cochin, INSERM, CNRS, F-75014, Paris, France., Lallemand A; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France., Certain A; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France., Autret G; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Université Paris Cité, Plateforme d'Imageries du Vivant, PARCC, F-75015, Paris, France., Mokrani Y; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France., Guillonneau F; Institut de Cancérologie de l'Ouest, CNRS UMR6075 INSERM U1307, 15 rue André Boquel, F-49055, Angers, France., Bruce J; Université Paris Cité, P53 proteom'IC facility, Institut Cochin, INSERM, CNRS, F-75014, Paris, France., Nguyen V; Sorbonne Université, Laboratoire d'Imagerie Biomédicale, Inserm, CNRS, F-75006, Paris, France., Gencer U; Service de Radiologie, AP-HP, hôpital européen Georges Pompidou, F-75015, Paris, France., Schmitt A; Université Paris Cité, Cochin Imaging, Electron microscopy, Institut Cochin, INSERM, CNRS, F-75014, Paris, France., Lager F; Université Paris Cité, Plateforme d'Imageries du Vivant, Institut Cochin, Inserm-CNRS, F-75014, Paris, France., Guilbert T; Université Paris Cité, Cochin Imaging Photonic, IMAG'IC, Institut Cochin, Inserm, CNRS, F-75014, Paris, France., Bruneval P; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France., Vilar J; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France., Maissa N; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France., Mousseaux E; Service de Radiologie, AP-HP, hôpital européen Georges Pompidou, F-75015, Paris, France., Viel T; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.; Université Paris Cité, Plateforme d'Imageries du Vivant, PARCC, F-75015, Paris, France., Renault G; Université Paris Cité, Plateforme d'Imageries du Vivant, Institut Cochin, Inserm-CNRS, F-75014, Paris, France., Kachenoura N; Sorbonne Université, Laboratoire d'Imagerie Biomédicale, Inserm, CNRS, F-75006, Paris, France., Tavitian B; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France. bertrand.tavitian@inserm.fr.; Université Paris Cité, Plateforme d'Imageries du Vivant, PARCC, F-75015, Paris, France. bertrand.tavitian@inserm.fr.; Service de Radiologie, AP-HP, hôpital européen Georges Pompidou, F-75015, Paris, France. bertrand.tavitian@inserm.fr.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2023 Jun 28; Vol. 14 (1), pp. 3835. Date of Electronic Publication: 2023 Jun 28.
DOI: 10.1038/s41467-023-39590-3
Abstrakt: Takotsubo cardiomyopathy is a stress-induced cardiovascular disease with symptoms comparable to those of an acute coronary syndrome but without coronary obstruction. Takotsubo was initially considered spontaneously reversible, but epidemiological studies revealed significant long-term morbidity and mortality, the reason for which is unknown. Here, we show in a female rodent model that a single pharmacological challenge creates a stress-induced cardiomyopathy similar to Takotsubo. The acute response involves changes in blood and tissue biomarkers and in cardiac in vivo imaging acquired with ultrasound, magnetic resonance and positron emission tomography. Longitudinal follow up using in vivo imaging, histochemistry, protein and proteomics analyses evidences a continued metabolic reprogramming of the heart towards metabolic malfunction, eventually leading to irreversible damage in cardiac function and structure. The results combat the supposed reversibility of Takotsubo, point to dysregulation of glucose metabolic pathways as a main cause of long-term cardiac disease and support early therapeutic management of Takotsubo.
(© 2023. The Author(s).)
Databáze: MEDLINE
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