A systematic review and meta-analysis on the efficacy of topical povidone iodine in adenoviral conjunctivitis.

Autor: González Martín-Moro J; Department of Ophthalmology, University Hospital of Henares, Av. de Marie Curie, 0, 28822 Coslada, Madrid, Spain; Faculty of Medicine, Universidad Francisco de Vitoria, Carretera Pozuelo, km 1800, 28223 Majadahonda, Madrid, Spain. Electronic address: juliogmm@yahoo.es., Zarallo-Gallardo J; Department of Ophthalmology, University Hospital of Henares, Av. de Marie Curie, 0, 28822 Coslada, Madrid, Spain; Faculty of Medicine, Universidad Francisco de Vitoria, Carretera Pozuelo, km 1800, 28223 Majadahonda, Madrid, Spain., Guzmán-Almagro E; Department of Ophthalmology, University Hospital of Henares, Av. de Marie Curie, 0, 28822 Coslada, Madrid, Spain., Antón Rodríguez C; Faculty of Medicine, Universidad Francisco de Vitoria, Carretera Pozuelo, km 1800, 28223 Majadahonda, Madrid, Spain.
Jazyk: angličtina
Zdroj: Contact lens & anterior eye : the journal of the British Contact Lens Association [Cont Lens Anterior Eye] 2023 Oct; Vol. 46 (5), pp. 101873. Date of Electronic Publication: 2023 Jun 26.
DOI: 10.1016/j.clae.2023.101873
Abstrakt: Purpose: To evaluate if topical povidone iodine (alone (PI) or combined with dexamethasone (PI-DXM)) is superior to placebo for treating adenoviral conjunctivitis (AC).
Methods: A systematic review was performed according to Preferred Reporting Items for the Systematic Review and Meta-Analyses (PRISMA) Statement. An electronic search was made on PubMed, Embase and Cochrane Library. Randomized control studies that compared PI or PI-DXM with placebo were included. At least three researchers were involved in all phases. Primary outcomes were AC duration and the number of clinical resolutions during the first week. Secondary outcomes were conjunctival redness and serous discharge one week after starting treatment and the rate of AC complications.
Results: Only five studies met the inclusion criteria. PI-DXM reduced the duration of the disease by 2.4 days (IC95% 4.09-0.71), however this result was based only in one study. PI and PI-DXM did not modify the probability of clinical resolution during the first week; relative risk (RR) = 1.77 (IC95% 0.63-4.96) and 1.70 (IC95% 0.67-4.36). The impact of PI on the probability of pseudomembranes could not be estimated. PI-DXM did not influence the risk of developing subepithelial infiltrates RR = 0.73 (IC95% 0.02-33.38).
Conclusions: At this time there is great uncertainty about the usefulness of PI on the course of adenoviral conjunctivitis. PI-DXM may have a small effect on AC duration. To make future reviews possible, it is important to standardize the way in which these results are reported. Futures studies should include etiological confirmation, unit of study (eyes vs patients) and report on those aspects that are more relevant for patient quality of life (duration of the disease, development of complications: pseudomembranes and subepithelial infiltrates).
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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