| Autor: |
Nsairat H; Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan., Ibrahim AA; Department of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC, USA., Jaber AM; Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan., Abdelghany S; Faculty of Pharmacy, The University of Jordan, Amman, Jordan., Atwan R; Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan., Shalan N; Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan., Abdelnabi H; Faculty of Pharmacy, The University of Jordan, Amman, Jordan.; Cell Therapy Center, The University of Jordan, Amman, Jordan., Odeh F; Department of Chemistry, The University of Jordan, Amman, Jordan., El-Tanani M; Pharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan.; Institute of Cancer Therapeutics, University of Bradford, Bradford, UK., Alshaer W; Cell Therapy Center, The University of Jordan, Amman, Jordan. |
| Abstrakt: |
Liposomes are spherical lipidic nanocarriers composed of natural or synthetic phospholipids with a hydrophobic bilayer and aqueous core, which are arranged into a polar head and a long hydrophobic tail, forming an amphipathic nano/micro-particle. Despite numerous liposomal applications, their use encounters many challenges related to the physicochemical properties strongly affected by their constituents, colloidal stability, and interactions with the biological environment. This review aims to provide a perspective and a clear idea about the main factors that regulate the liposomes' colloidal and bilayer stability, emphasising the roles of cholesterol and its possible alternatives. Moreover, this review will analyse strategies that offer possible approaches to provide more stable in vitro and in vivo liposomes with enhanced drug release and encapsulation efficiencies. |
