Prolonged dysbiosis and altered immunity under nutritional intervention in a physiological mouse model of severe acute malnutrition.

Autor:	Hidalgo-Villeda F; Aix Marseille University, CNRS, INSERM, CIML, Turing Centre for Living Systems, Marseille, France.; Escuela de Microbiología, Facultad de Ciencias, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.; IHU-Méditerranée Infection, Marseille, France., Million M; IHU-Méditerranée Infection, Marseille, France.; Ap-HM, Marseille, France., Defoort C; C2VN, INRA, INSERM, Aix Marseille University, CriBioM, Marseille, France., Vannier T; Aix Marseille University, CNRS, INSERM, CIML, Turing Centre for Living Systems, Marseille, France., Svilar L; C2VN, INRA, INSERM, Aix Marseille University, CriBioM, Marseille, France., Lagier M; Aix Marseille University, CNRS, INSERM, CIML, Turing Centre for Living Systems, Marseille, France., Wagner C; Aix Marseille University, CNRS, INSERM, CIML, Turing Centre for Living Systems, Marseille, France., Arroyo-Portilla C; Aix Marseille University, CNRS, INSERM, CIML, Turing Centre for Living Systems, Marseille, France.; Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica., Chasson L; Aix Marseille University, CNRS, INSERM, CIML, Turing Centre for Living Systems, Marseille, France., Luciani C; Aix Marseille University, CNRS, INSERM, CIML, Turing Centre for Living Systems, Marseille, France., Bossi V; Ap-HM, Marseille, France., Gorvel JP; Aix Marseille University, CNRS, INSERM, CIML, Turing Centre for Living Systems, Marseille, France., Lelouard H; Aix Marseille University, CNRS, INSERM, CIML, Turing Centre for Living Systems, Marseille, France., Tomas J; Aix Marseille University, CNRS, INSERM, CIML, Turing Centre for Living Systems, Marseille, France.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2023 May 19; Vol. 26 (6), pp. 106910. Date of Electronic Publication: 2023 May 19 (Print Publication: 2023).
DOI:	10.1016/j.isci.2023.106910
Abstrakt:	Severe acute malnutrition (SAM) is a multifactorial disease affecting millions of children worldwide. It is associated with changes in intestinal physiology, microbiota, and mucosal immunity, emphasizing the need for multidisciplinary studies to unravel its full pathogenesis. We established an experimental model in which weanling mice fed a high-deficiency diet mimic key anthropometric and physiological features of SAM in children. This diet alters the intestinal microbiota (less segmented filamentous bacteria, spatial proximity to epithelium), metabolism (decreased butyrate), and immune cell populations (depletion of LysoDC in Peyer's patches and intestinal Th17 cells). A nutritional intervention leads to a fast zoometric and intestinal physiology recovery but to an incomplete restoration of the intestinal microbiota, metabolism, and immune system. Altogether, we provide a preclinical model of SAM and have identified key markers to target with future interventions during the education of the immune system to improve SAM whole defects. Competing Interests: The authors declare no competing interests. (© 2023 The Author(s).)
Databáze:	MEDLINE
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