Correlation of systemic inflammation biomarkers and disease severity in pregnant women with COVID-19.

Autor:	Gündüz Ö; Ankara City Hospital, Ministry of Health, Department of Obstetrics and Gynecology - Ankara, Turkey., Seven B; Ankara City Hospital, Ministry of Health, Department of Obstetrics and Gynecology - Ankara, Turkey., Ozgu-Erdınc AS; University of Health Sciences, Ankara City Hospital, Ministry of Health, Department of Obstetrics and Gynecology - Ankara, Turkey., Ayhan SG; Ankara City Hospital, Ministry of Health, Department of Obstetrics and Gynecology - Ankara, Turkey., Sahin D; University of Health Sciences, Ankara City Hospital, Ministry of Health, Department of Obstetrics and Gynecology - Ankara, Turkey., Tekin OM; University of Health Sciences, Ankara City Hospital, Ministry of Health, Department of Obstetrics and Gynecology - Ankara, Turkey., Keskin HL; University of Health Sciences, Ankara City Hospital, Ministry of Health, Department of Obstetrics and Gynecology - Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2023 Jun 26; Vol. 69 (6), pp. e20221614. Date of Electronic Publication: 2023 Jun 26 (Print Publication: 2023).
DOI:	10.1590/1806-9282.20221614
Abstrakt:	Objective: The aim of this study was to evaluate the prognostic value of whole blood parameters, systemic inflammatory indices, and systemic inflammatory markers in pregnant women with COVID-19. Methods: In this cross-sectional study, the demographic, clinical, and laboratory data (i.e., whole blood parameters, C-reactive protein, procalcitonin, ferritin, and D-dimer) of 464 pregnant women with COVID-19 who attended a tertiary hospital between January and April 2021 were reviewed. Systemic inflammatory indices (i.e., neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, platelet/neutrophil ratio, and systemic immune inflammation index) were calculated. Asymptomatic and mildly symptomatic pregnant women were classified as Group 1 (n=413), and those with severe disease were classified as Group 2 (n=51). Results: Lymphocyte count and lymphocyte percentage in whole blood parameters were significantly lower (p<0.05), and C-reactive protein, ferritin, and procalcitonin values were higher in Group 2 (p<0.05). Systemic inflammatory indices [neutrophil/lymphocyte ratio (4.7±2.9 (1.1-21.2) vs 7.5±4.7 (2.13-23.2)), platelet/lymphocyte ratio (191.1±104.3 (53.0-807.1) vs 269.5±118.9 (105.0-756.0)), systemic immune inflammation index (1,000±663 (209-5,231) vs 1,630±1,314 (345-7,006))] were found statistically significantly higher in severe disease group (p<0.001). Conclusion: Evidence in this study indicates that neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and systemic immune inflammation index at first admission are simple, rapid, and inexpensive indices in predicting the prognosis of COVID-19 in pregnant women.
Databáze:	MEDLINE
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