Nationwide analysis of survival after radical cystectomy for bladder cancer in Finland.

Autor: Nikulainen I; Department of Urology, University of Turku and Turku University Hospital, Turku, Finland., Salminen AP; Department of Urology, University of Turku and Turku University Hospital, Turku, Finland., Seikkula H; Department of Surgery, Division of Urology, Central Hospital of Jyväskylä, Jyväskylä, Finland., Högerman M; Department of Urology, University of Turku and Turku University Hospital, Turku, Finland., Perez IM; Department of Information Technology, University of Turku, Turku, Finland.; Department of Biostatistics, University of Turku, Turku, Finland., Koskinen I; Department of Urology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Sairanen J; Department of Urology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Nikkola J; Department of Urology, University of Tampere and Tampere University Hospital, Tampere, Finland., Murtola TJ; Department of Urology, University of Tampere and Tampere University Hospital, Tampere, Finland., Vaarala MH; Department of Urology, University of Oulu and Oulu University Hospital, Oulu, Finland., Jousmäki S; Department of Urology, University of Oulu and Oulu University Hospital, Oulu, Finland., Nykopp TK; Department of Urology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Isotalo T; Department of Surgery, Division of Urology, Central Hospital of Lahti, Lahti, Finland., Marttila T; Department of Surgery, Division of Urology, Central Hospital of Seinäjoki, Seinäjoki, Finland., Alibeto A; Department of Surgery, Division of Urology, Central Hospital of Mikkeli, Mikkeli, Finland., Seppänen M; Department of Surgery, Division of Urology, Central Hospital of Pori, Pori, Finland., Palmberg C; Department of Surgery, Division of Urology, Central Hospital of Vaasa, Vaasa, Finland., Boström PJ; Department of Urology, University of Turku and Turku University Hospital, Turku, Finland.
Jazyk: angličtina
Zdroj: Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2023 Aug; Vol. 62 (8), pp. 829-835. Date of Electronic Publication: 2023 Jun 28.
DOI: 10.1080/0284186X.2023.2228446
Abstrakt: Background: Population-based survival results after radical cystectomy (RC) are limited. Our objective was to report short and long-term survival results after RC for bladder cancer from Finland in a population-based setting.
Materials and Methods: The Finnish National Cystectomy Database containing retrospectively collected essential RC data covering the years 2005-2017 was combined with the survival data from the Finnish Cancer Registry. Kaplan-Meier plots were used to estimate survival and the survival graphs were illustrated according to the final pathological staging. Centers were divided according to operational volume, and the results were then compared using Pearsons's Chi-squared test.
Results: A total of 2047 patients were included in the study. 30-, and 90-day mortality was 1.3%, and 3.8%, respectively. The OS of the entire RC population at 5- and 10 years was 66% and 55%, and CSS was 74% and 72%, respectively. Center volume did not significantly associate with surgical mortality or long-term survival. The 5- and 10-year OS according to pT-category was 87% and 74% for pT0, 85% and 69% for pTa-pTis-pT1, 70% and 58% for pT2, 50% and 42% for pT3 and 41% and 30% for pT4. The corresponding 5- and 10-year CSS rates were 96% and 93% for pT0, 91% and 90% for pTa-pTis-pT1, 78% and 75% for pT2, 56% and 55% for pT3 and 47% and 44% for pT4. The 5- and 10-year OS rates in patients with no lymph node metastases (pN-) were 74% and 62%, and CSS 82% and 80%, respectively. If lymph nodes were positive (pN+), the corresponding OS rates were 44% and 34% and CSS 49% and 48%, respectively.
Conclusion: RC survival results have improved in contemporary series and are associated with the pTNM-status. The nationwide results from Finland demonstrate outcome comparable to high volume single-center series.
Databáze: MEDLINE
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