| Autor: |
Rodrigues LLS; Programa de Pós-Graduação em Ciências da Saúde, Instituto de Saúde Coletiva, Universidade Federal do Oeste do Pará, Santarém 68135-110, Brazil.; Laboratório de AIDS e Imunologia Molecular, IOC-FIOCRUZ, Rio de Janeiro 21040-360, Brazil.; Programa de Pós-Graduação em Medicina Tropical, IOC-FIOCRUZ, Rio de Janeiro 21040-360, Brazil., Pilotto JH; Laboratório de AIDS e Imunologia Molecular, IOC-FIOCRUZ, Rio de Janeiro 21040-360, Brazil., Martinelli KG; Departamento de Medicina Social, Universidade Federal do Espírito Santo, Vitória 29075-910, Brazil., Nicol AF; Instituto Nacional de Infectologia Evandro Chagas, INI-FIOCRUZ, Rio de Janeiro 21040-360, Brazil., De Paula VS; Laboratório de Virologia Molecular e Parasitologia, IOC-FIOCRUZ, Rio de Janeiro 21040-360, Brazil., Gheit T; International Agency for Research on Cancer, 69366 Lyon, France., Oliveira NSC; Departamento de Patologia, Faculdade de Medicina, Universidade Federal Fluminense, Rio de Janeiro 23033-900, Brazil., Silva-de-Jesus C; Laboratório de AIDS e Imunologia Molecular, IOC-FIOCRUZ, Rio de Janeiro 21040-360, Brazil., Sahasrabuddhe VV; Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA., Da Silva DM; Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90033, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA., Kast WM; Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90033, USA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.; Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90089, USA., Hardick J; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Gaydos CA; Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Morgado MG; Laboratório de AIDS e Imunologia Molecular, IOC-FIOCRUZ, Rio de Janeiro 21040-360, Brazil. |
| Abstrakt: |
The aim of this study was to classify the diversity of anal HPV and non-HPV sexually transmitted infections (STIs) and compare the concordance between anal and genital infections in HIV-infected and uninfected women living in the Tapajós region, Amazon, Brazil. A cross-sectional study was performed with 112 HIV-uninfected and 41 HIV-infected nonindigenous women. Anal and cervical scrapings were collected and analyzed for HPV, Chlamydia trachomatis (CT) , Neisseria gonorrheae (NG), Trichomonas vaginalis (TV), Mycoplasma genitalium (MG), and Human alphaherpesvirus 2 (HSV-2). The Kappa test evaluated the concordance between anal and genital infections. The overall prevalence of anal HPV infection was 31.3% in HIV-uninfected and 97.6% in HIV-infected women. The most frequent anal high-risk HPV (hrHPV) types were HPV18 and HPV16 in HIV-uninfected women and HPV51, HPV59, HPV31, and HPV58 in HIV-infected women. Anal HPV75 Betapapillomavirus was also identified. Anal non-HPV STIs were identified in 13.0% of all participants. The concordance analysis was fair for CT, MG, and HSV-2, almost perfect agreement for NG, moderate for HPV, and variable for the most frequent anal hrHPV types. Thus, a high prevalence of anal HPV infection with moderate and fair concordance between anal and genital HPV and non-HPV STIs was observed in our study. |
