Preclinical EIS Study of the Inflammatory Response Evolution of Pure Titanium Implant in Hank's Biological Solution.

Autor: Benea L; Competences Center: Interfaces-Tribocorrosion-Electrochemical Systems, Dunarea de Jos University of Galati, 47 Domnească Street, RO-800008 Galati, Romania., Bounegru I; Competences Center: Interfaces-Tribocorrosion-Electrochemical Systems, Dunarea de Jos University of Galati, 47 Domnească Street, RO-800008 Galati, Romania., Forray A; Military Medicine Institute, Street Institutul Medico-Militar 3-5, RO-010919 Bucharest, Romania., Axente ER; Competences Center: Interfaces-Tribocorrosion-Electrochemical Systems, Dunarea de Jos University of Galati, 47 Domnească Street, RO-800008 Galati, Romania.; Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 35 Al. I. Cuza Street, RO-800010 Galati, Romania., Buruiana DL; Competences Center: Interfaces-Tribocorrosion-Electrochemical Systems, Dunarea de Jos University of Galati, 47 Domnească Street, RO-800008 Galati, Romania.; Faculty of Engineering, Dunarea de Jos University of Galati, 47 Domneasca Street, RO-800008 Galati, Romania.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2023 Jun 18; Vol. 28 (12). Date of Electronic Publication: 2023 Jun 18.
DOI: 10.3390/molecules28124837
Abstrakt: Pure titanium (Ti) is investigated in a pre-clinical study in Hank's biological solution using electrochemical methods, open circuit potential, and electrochemical impedance spectroscopy to highlight the time effect in extreme body conditions, such as inflammatory diseases, on degradability due to corrosion processes occurring on the titanium implant. Electrochemical impedance spectroscopy (EIS) data are presented as Nyquist and Bode plots. The results show the increasing reactivity of titanium implants in the presence of hydrogen peroxide, which is an oxygen-reactive compound that describes inflammatory conditions. The polarization resistance, which results from electrochemical impedance spectroscopy measurements, declined dramatically from the highest value registered in Hank's solution to smaller values registered in all solutions when different concentrations of hydrogen peroxide were tested. The EIS analysis provided insights into titanium's in vitro corrosion behavior as an implanted biomaterial, which could not be solely obtained through potentiodynamic polarization testing.
Databáze: MEDLINE
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