| Autor: |
López-Galán E; Departamento de Ciencias Básicas Biomédicas, Facultad de Medicina, Universidad de Ciencias Médicas de Santiago de Cuba, Santiago de Cuba 90100, Cuba., Vitón-Castillo AA; Facultad de Ciencias Médicas 'Dr. Ernesto Che Guevara de la Serna', Universidad de Ciencias Médicas de Pinar del Rio, Pinar del Rio 20100, Cuba., Carrazana-Escalona R; Departamento de Ciencias Clínicas Básicas, Facultad de Medicina, Universidad Católica de la Santísima Concepción, Concepción 4090541, Chile., Planas-Rodriguez M; Departamento de Ciencias Básicas Biomédicas, Facultad de Medicina, Universidad de Ciencias Médicas de Santiago de Cuba, Santiago de Cuba 90100, Cuba., Fernández-García AA; Facultad de Ciencias Naturales y Exactas, Universidad de Oriente, Santiago de Cuba 90100, Cuba., Cutiño-Clavel I; Departamento de Ciencias Básicas Biomédicas, Facultad de Medicina, Universidad de Ciencias Médicas de Santiago de Cuba, Santiago de Cuba 90100, Cuba., Pascau-Simon A; Hospital General 'Dr. Juan Bruno Zayas Alfonso', Laboratorio Vascular no Invasivo, Santiago de Cuba 90400, Cuba., Connes P; LIBM Laboratory, Team 'Vascular Biology and Red Blood Cell', Claude Bernard University Lyon 1, 69622 Lyon, France., Sánchez-Hechavarría ME; Grupo Bio-Bio Complejidad, Departamento de Ciencias Clínicas y Preclínicas, Facultad de Medicina, Universidad Católica de la Santísima Concepción, Concepción 4090541, Chile.; Núcleo Científico de Ciencias de la Salud, Facultad de Ciencias de la Salud, Universidad Adventista de Chile, Chillán 3780000, Chile., Muñoz-Bustos GA; Facultad de Ciencias de la Salud, Sede Concepción, Universidad de las Américas, Concepcion 4030000, Chile. |
| Abstrakt: |
Background and Objectives: To compare autonomic and vascular responses during reactive hyperemia (RH) between healthy individuals and patients with sickle cell anemia (SCA). Materials and Methods: Eighteen healthy subjects and 24 SCA patients were subjected to arterial occlusion for 3 min at the lower right limb level. The pulse rate variability (PRV) and pulse wave amplitude were measured through photoplethysmography using the Angiodin ® PD 3000 device, which was placed on the first finger of the lower right limb 2 min before (Basal) and 2 min after the occlusion. Pulse peak intervals were analyzed using time-frequency (wavelet transform) methods for high-frequency (HF: 0.15-0.4) and low-frequency (LF: 0.04-0.15) bands, and the LF/HF ratio was calculated. Results: The pulse wave amplitude was higher in healthy subjects compared to SCA patients, at both baseline and post-occlusion ( p < 0.05). Time-frequency analysis showed that the LF/HF peak in response to the post-occlusion RH test was reached earlier in healthy subjects compared to SCA patients. Conclusions: Vasodilatory function, as measured by PPG, was lower in SCA patients compared to healthy subjects. Moreover, a cardiovascular autonomic imbalance was present in SCA patients with high sympathetic and low parasympathetic activity in the basal state and a poor response of the sympathetic nervous system to RH. Early cardiovascular sympathetic activation (10 s) and vasodilatory function in response to RH were impaired in SCA patients. |
