| Autor: |
Vidas Pauk S; Department of Ophthalmology, Zagreb University Hospital Center, 10000 Zagreb, Croatia., Jandroković S; Department of Ophthalmology, Zagreb University Hospital Center, 10000 Zagreb, Croatia.; School of Medicine, University of Zagreb, Šalata 2, 10000 Zagreb, Croatia., Lešin Gaćina D; Department of Ophthalmology, Zagreb University Hospital Center, 10000 Zagreb, Croatia., Tomić M; Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital, Dugi dol 4a, 10000 Zagreb, Croatia., Bulum T; School of Medicine, University of Zagreb, Šalata 2, 10000 Zagreb, Croatia.; Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital, Dugi dol 4a, 10000 Zagreb, Croatia., Pupić Bakrač A; Department of Ophthalmology, Zagreb University Hospital Center, 10000 Zagreb, Croatia., Kuzman T; Department of Ophthalmology, Zagreb University Hospital Center, 10000 Zagreb, Croatia.; School of Medicine, University of Zagreb, Šalata 2, 10000 Zagreb, Croatia., Knežević J; Department of Ophthalmology, Zagreb University Hospital Center, 10000 Zagreb, Croatia., Kalauz M; Department of Ophthalmology, Zagreb University Hospital Center, 10000 Zagreb, Croatia.; School of Medicine, University of Zagreb, Šalata 2, 10000 Zagreb, Croatia. |
| Abstrakt: |
Purpose : To determine the 6-month effect of conventional (CXL30) and accelerated cross-linking with a UVA intensity of 9 mW/cm 2 (CXL10) on corneal stability and to investigate whether there was a difference in ABCD grading system parameters regarding the two different procedures. Methods : Twenty-eight eyes of 28 patients with a documented keratoconus (KN) progression were included. Patients were selected to undergo either epi off CXL30 or CXL10. At the baseline and the follow-up visits after one (V1), three (V2), and six months (V3), the patients underwent complete ophthalmic examination and corneal tomography. Results : In the CXL30 group, all the parameters from the ABCD grading system significantly changed from baseline to V3; parameter A decreased ( p = 0.048), B and C increased ( p = 0.010, p < 0.001), and D decreased ( p < 0.001). In the CXL10 group, there were no changes in parameters A ( p = 0.247) and B ( p = 0.933), though parameter C increased ( p = 0.001) and D decreased ( p < 0.001). After an initial decline after one month, visual acuity (VA) recovered on V2 and V3 ( p < 0.001), and median maximal keratometry (Kmax) decreased in both groups ( p = 0.001, p = 0.035). In the CXL30 group, there were significant changes in other parameters; average pachymetric progression index ( p < 0.001), Ambrósio relational thickness maximum (ARTmax) ( p = 0.008), front and back mean keratometry ( p < 0.001), pachymetry apex (PA) ( p < 0.001), and front elevation ( p = 0.042). However, in the CXL10 group, there were significant changes only in ARTmax ( p = 0.019) and PA ( p < 0.001). Conclusion : Both epi-off CXL protocols showed similar short-term efficacy in improving VA and Kmax, halting the progression of KN, and both similarly changed tomographic parameters. However, the conventional protocol modified the cornea more significantly. |
