"Lights and Shades" of Fertility Preservation in Transgender Men Patients: A Clinical and Pathological Review.

Autor: D'Amato A; Obstetrics and Gynaecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy., Cascardi E; Department of Medical Sciences, University of Turin, 10124 Turin, Italy.; Pathology Unit, FPO-IRCCS Candiolo Cancer Institute, 10060 Candiolo, Italy., Etrusco A; Unit of Gynecologic Oncology, ARNAS 'Civico-Di Cristina-Benfratelli', Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy., Laganà AS; Unit of Gynecologic Oncology, ARNAS 'Civico-Di Cristina-Benfratelli', Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy., Schonauer LM; Obstetrics and Gynaecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy., Cazzato G; Department of Emergency and Organ Transplantation, Pathology Section, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy., Vimercati A; Obstetrics and Gynaecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy., Malvasi A; Obstetrics and Gynaecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy., Damiani GR; Obstetrics and Gynaecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy., Di Naro E; Obstetrics and Gynaecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy., Trojano G; Obstetrics and Gynaecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy., Cicinelli E; Obstetrics and Gynaecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy., Vitagliano A; Obstetrics and Gynaecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy., Dellino M; Obstetrics and Gynaecology Unit, Department of Biomedical Sciences and Human Oncology, University of Bari 'Aldo Moro', Piazza Giulio Cesare 11, 70124 Bari, Italy.
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2023 Jun 01; Vol. 13 (6). Date of Electronic Publication: 2023 Jun 01.
DOI: 10.3390/life13061312
Abstrakt: Fertility preservation (FP) is becoming a critical issue in transgender men who desire biological offspring in the future. The prevalence of transgender individuals in the United States is increasing, and as a result, the demand for gender-affirming surgeries (GAS) and associated FP techniques is rising. Despite the growing demand, there is currently no personalized approach to FP for transgender men, and the available techniques have limitations that require further investigation. In the present review we carefully examine the existing literature on this topic to highlight the shortcomings of current methods and areas where additional research is needed to advance the field. Hormonal therapy (HT), which is an integral part of gender transition in transgender men, can have a significant impact on fertility and may increase the risk of various diseases. Moreover, GAS usually leads to permanent sterility in these patients. Therefore, it is essential to provide patients with accurate information about the benefits and potential risks of different FP techniques, taking into account the patient's reproductive goals. This review underscores the complex and multifaceted nature of FP in transgender men and emphasizes the need for further research to develop more effective and personalized approaches to FP for this population.
Databáze: MEDLINE
Nepřihlášeným uživatelům se plný text nezobrazuje