The Role of Pathogenesis Associated with the Tumor Microclimate in the Differential Diagnosis of Uterine Myocytic Tumors.

Autor: Bosoteanu M; Clinical Service of Pathology, Department of Pathology, 'Sf. Apostol Andrei' Emergency County Hospital, 900591 Constanta, Romania.; Department of Pathology, Faculty of Medicine, 'Ovidius' University of Constanţa, 900527 Constanta, Romania., Deacu M; Clinical Service of Pathology, Department of Pathology, 'Sf. Apostol Andrei' Emergency County Hospital, 900591 Constanta, Romania.; Department of Pathology, Faculty of Medicine, 'Ovidius' University of Constanţa, 900527 Constanta, Romania., Aschie M; Clinical Service of Pathology, Department of Pathology, 'Sf. Apostol Andrei' Emergency County Hospital, 900591 Constanta, Romania.; Department of Pathology, Faculty of Medicine, 'Ovidius' University of Constanţa, 900527 Constanta, Romania.; Academy of Medical Sciences of Romania, 030171 Bucharest, Romania., Vamesu S; Clinical Service of Pathology, Department of Pathology, 'Sf. Apostol Andrei' Emergency County Hospital, 900591 Constanta, Romania., Cozaru GC; Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology-CEDMOG, 'Ovidius' University of Constanţa, 900591 Constanta, Romania.; Clinical Service of Pathology, Department of Genetics, 'Sf. Apostol Andrei' Emergency County Hospital, 900591 Constanta, Romania., Mitroi AF; Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology-CEDMOG, 'Ovidius' University of Constanţa, 900591 Constanta, Romania.; Clinical Service of Pathology, Department of Genetics, 'Sf. Apostol Andrei' Emergency County Hospital, 900591 Constanta, Romania., Voda RI; Clinical Service of Pathology, Department of Pathology, 'Sf. Apostol Andrei' Emergency County Hospital, 900591 Constanta, Romania.; Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology-CEDMOG, 'Ovidius' University of Constanţa, 900591 Constanta, Romania., Orasanu CI; Clinical Service of Pathology, Department of Pathology, 'Sf. Apostol Andrei' Emergency County Hospital, 900591 Constanta, Romania.; Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology-CEDMOG, 'Ovidius' University of Constanţa, 900591 Constanta, Romania., Vlad SE; Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology-CEDMOG, 'Ovidius' University of Constanţa, 900591 Constanta, Romania., Penciu RC; Department of Obstetrics and Gynecology, Faculty of Medicine, 'Ovidius' University of Constanţa, 900527 Constanta, Romania., Chirila SI; Department of Medical Informatics and Biostatistics, Faculty of Medicine, Ovidius University, 900527 Constanta, Romania.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Jun 20; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 20.
DOI: 10.3390/jcm12124161
Abstrakt: Myocytic tumors of the uterus present vast morphological heterogeneity, which makes differential diagnosis between the different entities necessary. This study aims to enrich the existing data and highlight new potential therapeutic targets regarding aspects related to the pathogenic process and the tumor microenvironment in order to improve the quality of life of women. We performed a 5-year retrospective study, including particular cases of uterine myocyte tumors. Immunohistochemical analyses of pathogenic pathways (p53, RB1, and PTEN) and tumor microclimate using markers (CD8, PD-L1, and CD105), as well as genetic testing of the PTEN gene, were performed. The data were statistically analyzed using the appropriate parameters. In cases of atypical leiomyoma, a significant association was observed between PTEN deletion and an increased number of PD-L1+ T lymphocytes. For malignant lesions and STUMP, PTEN deletion was associated with the advanced disease stage. Advanced cases were also associated with an increased mean CD8+ T cell count. An increased number of lymphocytes was associated with an increased percentage of RB1+ nuclei. The study corroborated clinical and histogenetic data, highlighting the importance of the differential diagnosis of these tumors to improve the management of patients and increase their quality of life.
Databáze: MEDLINE
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