Are Local Drug Delivery Systems a Challenge in Clinical Periodontology?

Autor: Budală DG; Department of Implantology, Removable Prostheses, Dental Prostheses Technology, 'Grigore T. Popa' University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania., Luchian I; Department of Periodontology, Faculty of Dental Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania., Tatarciuc M; Department of Implantology, Removable Prostheses, Dental Prostheses Technology, 'Grigore T. Popa' University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania., Butnaru O; Department of Biophysics, Faculty of Dental Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 16 Universității Street, 700115 Iasi, Romania., Armencia AO; Department of Surgery and Oral Health, Faculty of Dental Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania., Virvescu DI; Department of Fixed Prosthodontics, Faculty of Dental Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 16 Universității Street, 700115 Iasi, Romania., Scutariu MM; Department of Implantology, Removable Prostheses, Dental Prostheses Technology, 'Grigore T. Popa' University of Medicine and Pharmacy, 16 Universității Street, 700115 Iași, Romania., Rusu D; Department of Periodontology, Faculty of Dental Medicine, 'Anton Sculean' Research Center for Periodontal and Peri-Implant Diseases, 'Victor Babes' University of Medicine and Pharmacy, Piața Eftimie Murgu 2, 300041 Timisoara, Romania.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Jun 19; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 19.
DOI: 10.3390/jcm12124137
Abstrakt: Placing antimicrobial treatments directly in periodontal pockets is an example of the local administration of antimicrobial drugs to treat periodontitis. This method of therapy is advantageous since the drug concentration after application far surpasses the minimum inhibitory concentration (MIC) and lasts for a number of weeks. As a result, numerous local drug delivery systems (LDDSs) utilizing various antibiotics or antiseptics have been created. There is constant effort to develop novel formulations for the localized administration of periodontitis treatments, some of which have failed to show any efficacy while others show promise. Thus, future research should focus on the way LDDSs can be personalized in order to optimize future clinical protocols in periodontal therapy.
Databáze: MEDLINE
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