In Vitro Characterization of Antioxidant, Antibacterial and Antimutagenic Activities of the Green Microalga Ettlia pseudoalveolaris .

Autor: Vornoli A; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Via Moruzzi 1, 56124 Pisa, Italy., Grande T; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Via Moruzzi 1, 56124 Pisa, Italy.; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Viale Morgagni 50, 50134 Florence, Italy., Lubrano V; Fondazione G. Monasterio, CNR/Regione Toscana, 56124 Pisa, Italy., Vizzarri F; National Agricultural and Food Centre Nitra, Hlohoveck'a 2, 95141 Lužianky, Slovakia., Gorelli C; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Via Moruzzi 1, 56124 Pisa, Italy., Raffaelli A; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Via Moruzzi 1, 56124 Pisa, Italy.; Crop Science Research Center, Scuola Superiore Sant'Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy., Della Croce CM; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Via Moruzzi 1, 56124 Pisa, Italy., Baca SZ; eCIER Research Group, Department of Biotechnology, Universidad Técnica del Norte, Av. 17 de Julio 5-21 y Gral. José María Córdova, Ibarra 100150, Ecuador., Sandoval C; eCIER Research Group, Department of Biotechnology, Universidad Técnica del Norte, Av. 17 de Julio 5-21 y Gral. José María Córdova, Ibarra 100150, Ecuador., Longo V; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Via Moruzzi 1, 56124 Pisa, Italy., Pozzo L; Institute of Agricultural Biology and Biotechnology (IBBA), National Research Council (CNR), Via Moruzzi 1, 56124 Pisa, Italy., Echeverria C; eCIER Research Group, Department of Biotechnology, Universidad Técnica del Norte, Av. 17 de Julio 5-21 y Gral. José María Córdova, Ibarra 100150, Ecuador.
Jazyk: angličtina
Zdroj: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Jun 20; Vol. 12 (6). Date of Electronic Publication: 2023 Jun 20.
DOI: 10.3390/antiox12061308
Abstrakt: Recently, green microalgae have gained importance due to their nutritional and bioactive compounds, which makes them some of the most promising and innovative functional foods. The aim of this study was to evaluate the chemical profile and the in vitro antioxidant, antimicrobial and antimutagenic activity of an aqueous extract of the green microalga Ettlia pseudoalveolaris , obtained from the freshwater lakes of the Ecuadorian Highlands. Human microvascular endothelial cells (HMEC-1) were used to determine the ability of the microalga to reduce the endothelial damage caused by hydrogen peroxide-induced oxidative stress. Furthermore, the eukaryotic system Saccharomyces cerevisiae was used to evaluate the possible cytotoxic, mutagenic and antimutagenic effect of E. pseudoalveolaris . The extract showed a notable antioxidant capacity and a moderate antibacterial activity mostly due to the high content in polyphenolic compounds. It is likely that the antioxidant compounds present in the extract were also responsible for the observed reduction in endothelial damage of HMEC-1 cells. An antimutagenic effect through a direct antioxidant mechanism was also found. Based on the results of in vitro assays, E. pseudoalveolaris proved to be a good source of bioactive compounds and antioxidant, antibacterial and antimutagenic capacities making it a potential functional food.
Databáze: MEDLINE
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