Full-Dose Intraoperative Electron Radiotherapy for Early Breast Cancer: Evidence from a Single Center's Experience.

Autor: Stefanelli A; Department of Radiation Oncology, University Hospital of Ferrara, 44121 Ferrara, Italy., Farina E; Department of Radiation Oncology, University Hospital of Ferrara, 44121 Ferrara, Italy., Mastella E; Department of Medical Physics, University Hospital of Ferrara, 44121 Ferrara, Italy., Fabbri S; Department of Medical Physics, University Hospital of Ferrara, 44121 Ferrara, Italy., Turra A; Department of Medical Physics, University Hospital of Ferrara, 44121 Ferrara, Italy., Bonazza S; Department of Surgery, University Hospital of Ferrara, 44121 Ferrara, Italy., De Troia A; Department of Surgery, University Hospital of Ferrara, 44121 Ferrara, Italy., Radica MK; Department of Surgery, University Hospital of Ferrara, 44121 Ferrara, Italy., Carcoforo P; Department of Surgery, University Hospital of Ferrara, 44121 Ferrara, Italy.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 Jun 19; Vol. 15 (12). Date of Electronic Publication: 2023 Jun 19.
DOI: 10.3390/cancers15123239
Abstrakt: To evaluate the clinical response rate and cosmetic outcome after full-dose intraoperative electron radiotherapy (IOERT) in early breast cancer (BC) treated with conserving surgery. Inclusion criteria were: >60 years old, clinical tumor size ≤2 cm, luminal A carcinoma, patological negative lymph nodes, excluded lobular carcinoma histology. IOERT was delivered with a dose of 21 Gy at 90% isodose. Clinical, cosmetic and/or instrumental follow-up were performed 45 days after IOERT, 6 months after the first check, and every 12 months thereafter. Acute and late toxicities were assessed with the CTCAE v.4.03 and EORTC-RTOG scales, respectively. Cosmetic outcome was evaluated using the Harvard/NSABO/RTOG Breast Cosmesis Grading Scale. Overall, 162 consecutive patients were included in this analysis (median follow-up: 54 months, range: 1-98 months). The overall response rate was 97.5% (CI 95%: 0.93-0.99%). Locoragional relapse occurred in 2.5% of patients. No patient showed distant metastases. No patient showed radiation-related acute complications, with 3.7% showing late G2-3 toxicity. Only 3.7% of patients showed poor cosmetic results. Our data confirmed that IOERT is a feasible and valid therapeutic option in low-risk BC patients treated with lumpectomy. A low local recurrence rate combined with good cosmetic results validates the settings of our operative method in routinely clinical practice.
Databáze: MEDLINE
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