Electrochemical sensor based on the synergy between Cucurbit[8]uril and 2D-MoS 2 for enhanced melatonin quantification.

Autor: Martínez-Moro R; Departamento de Química Analítica y Análisis Instrumental. Facultad de Ciencias, c/ Francisco Tomás y Valiente, Nº7. Campus de Excelencia de la Universidad Autónoma de Madrid, 28049, Madrid, Spain., Del Pozo M; Departamento de Química Analítica y Análisis Instrumental. Facultad de Ciencias, c/ Francisco Tomás y Valiente, Nº7. Campus de Excelencia de la Universidad Autónoma de Madrid, 28049, Madrid, Spain., Vázquez L; Instituto de Ciencia de Materiales de Madrid (CSIC), c/ Sor Juana Inés de la Cruz Nº3. Campus de Excelencia de la Universidad Autónoma de Madrid, 28049, Madrid, Spain., Martín-Gago JA; Instituto de Ciencia de Materiales de Madrid (CSIC), c/ Sor Juana Inés de la Cruz Nº3. Campus de Excelencia de la Universidad Autónoma de Madrid, 28049, Madrid, Spain., Petit-Domínguez MD; Departamento de Química Analítica y Análisis Instrumental. Facultad de Ciencias, c/ Francisco Tomás y Valiente, Nº7. Campus de Excelencia de la Universidad Autónoma de Madrid, 28049, Madrid, Spain., Casero E; Departamento de Química Analítica y Análisis Instrumental. Facultad de Ciencias, c/ Francisco Tomás y Valiente, Nº7. Campus de Excelencia de la Universidad Autónoma de Madrid, 28049, Madrid, Spain. elena.casero@uam.es., Quintana C; Departamento de Química Analítica y Análisis Instrumental. Facultad de Ciencias, c/ Francisco Tomás y Valiente, Nº7. Campus de Excelencia de la Universidad Autónoma de Madrid, 28049, Madrid, Spain. carmen.quintana@uam.es.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Jun 27; Vol. 13 (1), pp. 10378. Date of Electronic Publication: 2023 Jun 27.
DOI: 10.1038/s41598-023-37401-9
Abstrakt: We present the development of an electrochemical sensor towards melatonin determination based on the synergistic effect between MoS 2 nanosheets and cucurbit[8]uril. For the sensor construction cucurbit[8]uril suspensions were prepared in water, and MoS 2 nanosheets were obtained by liquid exfoliation in ethanol:water. The sensing platform was topographically characterized by Atomic Force Microscopy. Electrochemical Impedance Spectroscopy experiments allowed us to study the charge transfer process during melatonin oxidation. Moreover, stoichiometry of the resulting complex has also been determined. After the optimization of the sensor construction and the experimental variables involved in the Differential Pulse Voltammetric response of melatonin, detection limit of 3.80 × 10 -7  M, relative errors minor than 3.8% and relative standard deviation lower than 4.4% were obtained. The proposed sensor has been successfully applied to melatonin determination in pharmaceutical and biological samples as human urine and serum, with very good recoveries ranging from 90 to 102%.
(© 2023. The Author(s).)
Databáze: MEDLINE
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